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Saline IV
Saline IV replaces lost fluids and electrolytes to restore normal blood volume and osmotic balance.
Saline IV replaces lost fluids and electrolytes to restore normal blood volume and osmotic balance. Used for Fluid resuscitation and volume replacement in dehydration, Maintenance fluid therapy, Vehicle for intravenous drug administration.
At a glance
| Generic name | Saline IV |
|---|---|
| Also known as | Sodium chloride, IV saline |
| Sponsor | Rhode Island Hospital |
| Drug class | Crystalloid fluid / Electrolyte replacement |
| Modality | Small molecule |
| Therapeutic area | Supportive Care / Fluid Management |
| Phase | FDA-approved |
Mechanism of action
Intravenous saline is a sterile solution of sodium chloride in water that directly replenishes intravascular fluid volume and maintains electrolyte homeostasis. It is used for fluid resuscitation, maintenance therapy, and as a vehicle for drug delivery in clinical settings. The solution equilibrates across fluid compartments to restore hydration status.
Approved indications
- Fluid resuscitation and volume replacement in dehydration
- Maintenance fluid therapy
- Vehicle for intravenous drug administration
- Electrolyte replacement
Common side effects
- Hyperchloremic acidosis
- Fluid overload / pulmonary edema
- Hypokalemia
- Phlebitis at infusion site
Key clinical trials
- Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial. (NA)
- Magnesium Supplementation in Advanced Non-small Cell Lung Cancer (NSCLC) (PHASE2, PHASE3)
- Safety Evaluation of PfSPZ Vaccine in Pregnant Women in Mali (MalVIP1) (PHASE1)
- Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies (PHASE1)
- Impact of Sugammadex Versus Neostigmine on Early Postoperative Pulmonary Function (NA)
- MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM) (PHASE3)
- Sphenopalatine Ganglion Block for Post-Dural Puncture Headache: A Pilot Randomised Controlled Trial (NA)
- A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |