NCT05446727

Quadratus Lumborum Block vs Erector Spinal Block for Post Abdomen Surgery Analgesia

Completed NA Last updated 4 September 2025

What this trial tests

NA trial testing Ropivacaine injection in Pain, Acute in 100 participants. Completed in 31 December 2023.

Timeline

1 May 2022

Primary endpoint
6 May 2022

31 December 2023

Quick facts

Lead sponsor	Jagiellonian University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	100
Start date	1 May 2022
Primary completion	6 May 2022
Estimated completion	31 December 2023
Sites	1 location across Poland

Drugs / interventions tested

• Ropivacaine injection — full drug profile →

Conditions studied

• Pain, Acute — all drugs for Pain, Acute →
• Postoperative Pain — all drugs for Postoperative Pain →
• Anesthetics, Local — all drugs for Anesthetics, Local →

Sponsor

Jagiellonian University

Who can join

Adults 18 to 90, any sex, with Pain, Acute or Postoperative Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Prior to surgery, patients will be stratified into groups according to the type of surgical procedure. The anticipated groups are as follows:

Patients with colorectal cancer

Patients with prostate cancer

Patients with renal cancer

Patients undergoing surgery for gallbladder cholelithiasis. The Erector Spinal Block (ESP) is based on the deposition of the local anesthetic in the inter-fascial space between the dorsal extensor muscle and the intercostal muscles at the height of the transverse processes. The scope of the blockade covers the dorsal and ventral branches of the thoracic spinal nerves, but also in most cases the investigetors are able to obtain a wide distribution of the drug into the paravertebral space by "permeating" the local anesthetic through the fascial compartments. The clinical effect of the blockade is due to blocking the nerve structures of the paravertebral space (spinal nerve branches and the sympathetic trunk). The scope of the blockade, after its execution at the level of Th5, most often includes the segments from Th1 to L1.

Currently, the Quadratus Lumborum block (QL block) is performed as one of the perioperative pain management procedures for all generations (pediatrics, pregnant, and adult) undergoing abdominal surgery. The local anesthetic injected via the approach of the anterior QL block ( QL1 block ) can more easily extend beyond the TAP to the thoracic paravertebral space or the thoracolumbar plane, the posterior QL block entails a broader sensory-level analgesic and may generate analgesia from T7 to L1.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Effects of erector spinae plane block and quadratus lumborum block on postoperative opioid consumption in laparoscopic prostatectomy: a randomized controlled clinical trial.
   Składzień T, Maciejewski P, Szpunar W, Lonc T, et al · · 2025 · PMID 41099275 · DOI 10.5114/ait/210670
2. Effects of Erector Spinae Plane Block and Quadratus Lumborum Block on Postoperative Opioid Consumption in Laparoscopic Kidney Surgery: A Randomized Controlled Clinical Trial.
   Tomasz S, Pawel M, Michal C, Szpunar W, et al · · 2025 · PMID 40791636 · DOI 10.1155/prm/8869716