A Randomized Comparison Between 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg of Perineural Dexmedetomidine for Ultrasound-Guided Infraclavicular Block

NCT07249827 PHASE2 RECRUITING

This study will compare three different doses of perineural dexmedetomidine 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg as adjuvants to local anesthetics for ultrasound-guided infraclavicular brachial plexus blocks (ICBs). Our research hypothesis is that 1.33 mcg/kg will provide a 15%-longer duration than 1mcg/kg, which in turn will provide a 15%-longer duration than 0.67 mcg/kg. Since analgesic duration and sensory duration can be influenced by intake of pain medications and surgical trauma to small cutaneous nerves, respectively, we will select motor block duration as the main outcome to better target the action of dexmedetomidine on the brachial plexus.

Details

Lead sponsor	McGill University Health Centre/Research Institute of the McGill University Health Centre
Phase	PHASE2
Status	RECRUITING
Enrolment	69
Start date	Sun Dec 28 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Tue Jun 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Analgesia
• Pain, Acute
• Upper Extremity Surgery
• Nerve Block

Interventions

• dexmedetomidine (perineural) 0.67 mcg/kg
• dexmedetomidine (perineural) 1 mcg/kg
• dexmedetomidine (perineural) 1.33 mcg/kg

Countries

Canada