Who is sponsoring NCT05889741?

NCT05889741 is sponsored by The University of Texas Health Science Center at San Antonio.

What condition does NCT05889741 study?

NCT05889741 studies Stress Disorders, Post-Traumatic.

What drugs are being tested in NCT05889741?

Interventions: Ropivacaine injection, Normal saline.

What is the status of NCT05889741?

NCT05889741 is currently RECRUITING.

Last reviewed 2025-09-04 · How we verify

Combining Stellate Ganglion Block With Prolonged Exposure for PTSD

NCT05889741 PHASE2 RECRUITING

The goal of this clinical trial is to compare the combination of Massed Prolonged Exposure (PE); a behavioral therapy for PTSD) and a stellate ganglion block (SGB; an injection of a local anesthetic into the front of the neck) with Massed Prolonged Exposure and a sham injection in a sample of military service members or retirees with PTSD. The main questions it aims to answer are: (1) Does the addition of an SGB improve treatment outcomes associated with Massed PE and (2) Do differences in psychophysiological arousal during the exposure portion of treatment help explain treatment outcomes for PTSD. Participants will receive ten 90-minute session of Massed PE. Between the first and second Massed PE sessions, half of the participants will receive a SGB, and half will receive a sham SGB.

Details

Lead sponsor	The University of Texas Health Science Center at San Antonio
Phase	PHASE2
Status	RECRUITING
Enrolment	140
Start date	Mon Feb 26 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Tue Aug 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Stress Disorders, Post-Traumatic

Interventions

Ropivacaine injection
Normal saline

Countries

United States