NCT05402150

An Online Intervention Targeting Depression and Low Reward Sensitivity

Completed NA Last updated 3 October 2023

What this trial tests

NA trial testing Behavioral Activation in Depression Mild in 224 participants. Completed in 15 September 2023.

Timeline

30 May 2022

Primary endpoint
15 May 2023

15 September 2023

Quick facts

Lead sponsor	Philipps University Marburg
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	factorial
Masking	none
Primary purpose	treatment
Enrollment	224
Start date	30 May 2022
Primary completion	15 May 2023
Estimated completion	15 September 2023
Sites	1 location across Germany

Drugs / interventions tested

• Behavioral Activation
• Mindulness and Gratitude
• Combination of Behavioral Activation and Mindfulness and Gratitude

Conditions studied

• Depression Mild — all drugs for Depression Mild →
• Depression Moderate — all drugs for Depression Moderate →

Sponsor

Philipps University Marburg

Who can join

18 and older, any sex, with Depression Mild or Depression Moderate. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to evaluate and compare the effectiveness of different online interventions targeting reward sensitivity and depressive symptoms. We hypothesize that behavioral activation, a mindfulness and gratitude intervention, as well as a combination of both, will significantly reduce depressive symptoms and increase reward sensitivity, compared to the waitlist group. In addition, we assume that behavioral activation will have an increased effect on reward sensitivity compared to the mindfulness and gratitude intervention.

The investigators will further investigate factors influencing treatment success in another paper based on data of this study (see secondary and other pre-specified outcome measures).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Effectiveness of behavioral activation and mindfulness in increasing reward sensitivity and reducing depressive symptoms - A randomized controlled trial.
   Potsch L, Rief W. · · 2024 · cited 9× · PMID 38128402 · DOI 10.1016/j.brat.2023.104455