Last reviewed · How we verify
NCT05685511
Behavioral Activation and Medication Optimization For Improving Perioperative Mental Health In Older Adults Undergoing Oncologic Surgery
NA trial testing Behavioral Activation in Older Adults in 105 participants. Completed in 12 July 2024.
12 July 2024
Quick facts
| Lead sponsor | Washington University School of Medicine |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 105 |
| Start date | 10 March 2023 |
| Primary completion | 12 July 2024 |
| Estimated completion | 12 July 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Behavioral Activation
- Medication Optimization — full drug profile →
- Usual care resources
Conditions studied
- Older Adults — all drugs for Older Adults →
- Anxiety — all drugs for Anxiety →
- Depression — all drugs for Depression →
- Major Surgical Resection of a Thoracic Malignancy — all drugs for Major Surgical Resection of a Thoracic Malignancy →
Sponsor
Washington University School of Medicine
Who can join
60 and older, any sex, with Older Adults or Anxiety. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Using a Hybrid Type 1 Effectiveness-Implementation randomized control trial (RCT) design, the investigators will test the effectiveness of a bundled behavioral activation and medication optimization in reducing symptoms of depression and anxiety in older adults undergoing oncologic surgery (compared with usual care), while examining implementation outcomes.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
A Perioperative Mental Health Intervention for Depressed and Anxious Older Surgical Patients: Results From a Feasibility Study.
Abraham J, Holzer KJ, Lenard EM, Meng A, et al · · 2024 · cited 22× · PMID 37798223 · DOI 10.1016/j.jagp.2023.09.003 -
A multi- and mixed-method adaptation study of a patient-centered perioperative mental health intervention bundle.
Abraham J, Meng A, Baumann A, Holzer KJ, et al · · 2023 · cited 13× · PMID 37891574 · DOI 10.1186/s12913-023-10186-3 -
Perioperative mental health intervention for depression and anxiety symptoms in older adults study protocol: design and methods for three linked randomised controlled trials.
Holzer KJ, Bartosiak KA, Calfee RP, Hammill CW, et al · · 2024 · cited 4× · PMID 38569683 · DOI 10.1136/bmjopen-2023-082656 -
Brain-Hazardous Medications and Potential Subadequate Antidepressant Dosing in Older Surgical Patients Receiving Home Antidepressants: An Observational Study of a Large US Health System.
Pennington BRT, Holzer KJ, Fritz BA, Haroutounian S, et al · · 2024 · cited 3× · PMID 38507476 · DOI 10.1213/ane.0000000000006952
Verify or expand the search:
- PubMed search for NCT05685511
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Behavioral Activation
Trials testing the same drug.
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- NCT05574127 — A Study of Brief Behavioral Activation for the Treatment of Depression in Older Adult Cancer Survivors · Phase 2 · active not recruiting
- NCT06072209 — Long-term Effects ReSet Your Mind - Mechanisms · NA · completed
Other recruiting trials for Older Adults
Currently open trials in the same condition.
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- NCT07054840 — Pain and Split-belt Motor Learning in Older Adults · NA · recruiting
- NCT07107191 — Dysfunctional Breathing and Physical Fitness in Older Adults · recruiting
- NCT06901700 — Effects of Home-based Lower Extremity Muscle Power Training on Functional Muscle and Balance Performance in Older Adults · NA · recruiting
Other Washington University School of Medicine trials
Trials by the same sponsor.
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- NCT07200089 — Recombinant Human IL-7 (NT-I7) in Relapsed/Refractory Multiple Myeloma Following BCMA CAR-T Therapy (Cilta-cel) · Phase 1 · not yet recruiting
- NCT07313592 — Whole Genome Sequencing (ChromoSeq®) for Acute Lymphoblastic Leukemia (ALL) Patients · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05685511 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Washington University School of Medicine
- Last refreshed: 31 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05685511.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing