NCT05357066 is a Phase 2 clinical trial of Nitrous oxide gas for inhalation in Fibromyalgia, sponsored by University of Chicago.

Who is sponsoring NCT05357066?

NCT05357066 is sponsored by University of Chicago.

What drugs are being tested in NCT05357066?

Interventions in NCT05357066: Nitrous oxide gas for inhalation, Placebo.

What condition does NCT05357066 study?

NCT05357066 studies Fibromyalgia, Central Neuropathic Pain.

Is NCT05357066 still recruiting?

NCT05357066 is currently recruiting now. Last updated 12 January 2026.

Last reviewed 2026-01-12 · How we verify

NCT05357066

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Nitrous Oxide as Treatment for Fibromyalgia

Recruiting now Phase 2 Last updated 12 January 2026

What this trial tests

Phase 2 trial testing Nitrous oxide gas for inhalation in Fibromyalgia in 50 participants. Currently enrolling.

Timeline

12 November 2021

Primary endpoint
1 June 2027

1 December 2027

Quick facts

Lead sponsor	University of Chicago
Phase	Phase 2
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	50
Start date	12 November 2021
Primary completion	1 June 2027
Estimated completion	1 December 2027
Sites	1 location across United States

Drugs / interventions tested

Nitrous oxide gas for inhalation — full drug profile →
Placebo

Conditions studied

Fibromyalgia — all drugs for Fibromyalgia →
Central Neuropathic Pain — all drugs for Central Neuropathic Pain →

Sponsor

University of Chicago

Who can join

Adults 18 to 75, any sex, with Fibromyalgia or Central Neuropathic Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to explore a potential role of nitrous oxide in treating pain associated with fibromyalgia.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Various gases for the treatment of neuropathic pain: mechanisms, current status, and future perspectives.
Liu Y, Shen T, Li Q, Yu X, et al · · 2025 · cited 6× · PMID 40300884 · DOI 10.4103/mgr.medgasres-d-24-00161

Verify or expand the search:

Other trials of Nitrous oxide gas for inhalation

Trials testing the same drug.

NCT05710887 — N2O for Acute Suicidality and Depression in the ED · Phase 2 · withdrawn
NCT05528718 — SMILE Trial - Imaging Sub-Study · completed
NCT05357040 — Antidepressant Effects of Nitrous Oxide · Phase 2 · recruiting
NCT04089852 — Nitrous Oxide for Pain Management During IUD Insertion in Nulliparous Adolescent Women · Phase 2, PHASE3 · withdrawn

Other recruiting trials for Fibromyalgia

Currently open trials in the same condition.

NCT02285868 — ATI Evidence-based Guide Investigating Clinical Services · active not recruiting
NCT07245303 — Neural Mechanisms of Light Driven Analgesia · NA · recruiting
NCT05901259 — The EXOPULSE Study - a Database for Routine Follow-up of Clinical Outcomes · recruiting
NCT07358754 — The Relationship Between Serum S100B and Brain-Derived Neurotrophic Factor · recruiting
NCT07465991 — The Effect of Digital Cognitive Behavioural Therapy for Insomnia on Physical Activity in Fibromyalgia · NA · recruiting

Other University of Chicago trials

Trials by the same sponsor.

NCT07346196 — A Trial of Locoregionally Advanced Squamous Cell Carcinoma of The Head and Neck · Phase 2 · not yet recruiting
NCT07354100 — Lactulose to Improve Gut Health in Cancer Patients Receiving Immunotherapy · Phase 1, PHASE2 · not yet recruiting
NCT06446661 — Using Text Messages to Improve Oral Chemotherapy for Adolescents and Adults With Acute Lymphoblastic Leukemia · NA · not yet recruiting
NCT07179315 — A Study Comparing Two Immunotherapy Options for Human Papillomavirus Positive HPV-Positive Head and Neck Cancer After Tr · Phase 2 · not yet recruiting
NCT07126561 — Trastuzumab Deruxtecan to Treat HER2 + Newly Diagnosed Metastatic GI Cancers · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05357066 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Chicago
Last refreshed: 12 January 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05357066.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing