Last reviewed · How we verify
NCT07245303
Neural Mechanisms of Light Driven Analgesia
NA trial testing S-cone modulating visual stimulus in Musculoskeletal Pain in 60 participants. Currently enrolling.
31 January 2030
Quick facts
| Lead sponsor | University of North Carolina, Chapel Hill |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | other |
| Enrollment | 60 |
| Start date | 24 February 2026 |
| Primary completion | 31 January 2030 |
| Estimated completion | 31 January 2030 |
| Sites | 1 location across United States |
Drugs / interventions tested
- S-cone modulating visual stimulus
- Equal Energy White Visual Stimulus
- Green light visual stimulus (S-OFF)
- Evoked Pressure Pain Stimulus
Conditions studied
- Musculoskeletal Pain — all drugs for Musculoskeletal Pain →
- Fibromyalgia — all drugs for Fibromyalgia →
- Healthy Controls Group - Age and Sex-matched — all drugs for Healthy Controls Group - Age and Sex-matched →
Sponsor
University of North Carolina, Chapel Hill
Who can join
18 and older, any sex, with Musculoskeletal Pain or Fibromyalgia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this study will be to understand the biological mechanisms that are responsible to light-driven analgesia. Light presented to the retina has been shown to have pain relieving properties in pre-clinical and clinical studies. In this study the investigators will evaluate the functional connectivity between subcortical visual areas and non-image forming brain areas that are involved in pain sensation. The investigators will also evaluate how three colored light stimuli presented to the retina results in changes in whole brain evoked activation patterns in participants with chronic musculoskeletal pain and in healthy controls. The investigators will also assess while brain evoked activation patterns in response to a pressure pain stimulus in the presence of three light stimuli in individuals with chronic musculoskeletal pain and healthy controls.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07245303
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07245303 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of North Carolina, Chapel Hill
- Last refreshed: 13 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07245303.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing