NCT05295862: GIST

Giessen Stroke Registry

Recruiting now Last updated 1 December 2023

What this trial tests

trial in Stroke, Acute in 2,000 participants. Currently enrolling.

Timeline

30 November 2023

Primary endpoint
31 December 2026

31 December 2027

Quick facts

Lead sponsor	University of Giessen
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	2,000
Start date	30 November 2023
Primary completion	31 December 2026
Estimated completion	31 December 2027
Sites	1 location across Germany

Conditions studied

• Stroke, Acute — all drugs for Stroke, Acute →
• Comorbidities and Coexisting Conditions — all drugs for Comorbidities and Coexisting Conditions →
• Critical Care — all drugs for Critical Care →

Sponsor

University of Giessen

Who can join

18 and older, any sex, with Stroke, Acute or Comorbidities and Coexisting Conditions. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of the planned study project is to assess the current situation regarding the treatment of patients with stroke. Specifically, various treatment strategies are to be associated and correlated with clinical endpoints, mortality or functional outcome in order to generate arguments for or against individual aspects of therapy. The focus will be on unresolved treatment approaches in acute therapy (e.g. periprocedural management, such as blood pressure, blood glucose, temperature, or airway management, during recanalizing therapies) as well as in secondary prevention on the stroke unit or intensive care unit, such as starting point, mode, and dosage of antithrombotic therapies.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. 11th European Stroke Organisation Conference Abstracts - 21-23 May 2025, Helsinki, Finland.
   · 2025 · cited 3× · PMID 40726475 · DOI 10.1177/23969873251329993
2. Comparison of vascular risk profile and clinical outcomes among patients with central (branch) retinal artery occlusion versus amaurosis fugax.
   Diel NJ, Gerner ST, Doeppner TR, Juenemann M, et al · · 2024 · cited 2× · PMID 38750601 · DOI 10.1186/s42466-024-00326-3
3. Rendezvous intervention using combined surgical carotid endarterectomy followed by endovascular thrombectomy in patients with acute tandem occlusions: a proof-of-concept experience at a tertiary care center.
   Diel NJ, Gerner ST, Alhaj Omar O, Kalder J, et al · · 2023 · cited 2× · PMID 38057910 · DOI 10.1186/s42466-023-00290-4
4. Comparative effectiveness of Tenecteplase and Alteplase for ischemic stroke: real-world data from a stroke center.
   Maxhuni T, Culaj F, Sayar MM, Böttger P, et al · · 2026 · cited 1× · PMID 41572186 · DOI 10.1186/s12883-026-04655-5
5. Combining Coronal and Axial DWI for Accurate Diagnosis of Brainstem Ischemic Strokes: Volume-Based Correlation with Stroke Severity.
   Alhaj Omar O, Yenigün M, Alchayah F, Boettger P, et al · · 2025 · cited 1× · PMID 40867156 · DOI 10.3390/brainsci15080823
6. Radiologic drivers of dysphagia after intracerebral haemorrhage: a flexible endoscopic evaluation of swallowing-guided retrospective analysis on intensive care unit.
   Hamzic S, Alhaj Omar O, Danielczik L, Gerner ST, et al · · 2026 · PMID 42121197 · DOI 10.1186/s42466-026-00498-0
7. Imaging and clinical outcomes of COVID-19- vs. non-COVID-19-related cerebral venous thrombosis.
   Maxhuni T, Doeppner TR, Braun T, Emde J, et al · · 2024 · PMID 41542238 · DOI 10.3389/fstro.2024.1396507
8. Evaluating the Safety and Efficacy of Intravenous Thrombolysis in Acute Ischemic Stroke Patients Without Perfusion Deficit: A Retrospective Analysis.
   Alhaj Omar O, Gerner ST, Alikevitch S, Hamzic S, et al · · 2025 · PMID 41154133 · DOI 10.3390/brainsci15101034