NCT05281705

Feasibility@48: Cross Sectional Study of Intensive Care Unit Mobility Practices Across the United Kingdom

Status unknown Last updated 31 March 2022

What this trial tests

trial in Critical Illness in 750 participants. Status unknown.

Timeline

3 March 2022

Primary endpoint
3 March 2022

30 March 2023

Quick facts

Lead sponsor	University College, London
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	750
Start date	3 March 2022
Primary completion	3 March 2022
Estimated completion	30 March 2023
Sites	1 location across United Kingdom

Conditions studied

• Critical Illness — all drugs for Critical Illness →
• Rehabilitation — all drugs for Rehabilitation →

Sponsor

University College, London

Who can join

18 and older, any sex, with Critical Illness or Rehabilitation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Intensive Care Unit (ICU) patients commonly experience muscle loss at a rate of 2-3% day. Traditionally, critically ill patients have been managed in bed, however current research suggests that prolonged bedrest cause mechanical silencing of the muscles and exacerbates this muscle wasting. This ICU acquired weakness (ICUAW) leads to poor functional outcome and higher mortality. Research suggests that early out-of-bed mobilisation should occur within 48-hours of ICU admission to militate against this risk, however, this is only achieved in 30% of cases. Common barriers to mobilisation are unstable blood pressure, ventilation, sedation and fatigue. It is plausible that 48-hours is an unrealistic timeframe for mobilisation.

The aim of this study is to explore the mobility practices on a given day in UK adult ICUs. The objectives are to:

1. Determine the level of mobility that is achieved by each patient on adult ICUs, on a given day in the UK.
2. Determine the typical physiological profile of patients on ICU that are both able and unable to participate in antigravity exercise
3. Determine the proportion of adult ICU admissions that achieve out of bed mobilisation in the first 48-72 hours
4. Explore clinician decision making about mobilisation

This is a multi-centre cross-sectional study on one-day only. Over a 24-hour period data will be collected for all ICU patients at the participating centres. The lead physiotherapist will record the highest level of mobility achieved that day, and the physiological parameters from clinical observations. The reasons for the level of mobility achieved will be ranked in order of importance. These data are routinely collected. Data will be anonymised.

Data will be analysed to determine feasibility of mobilisation at 48hours and develop a flow diagram of mobilisation decision-making.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Feasibility of mobilisation in ICU: a multi-centre point prevalence study of mobility practices in the UK.
   Black C, Sanger H, Battle C, Eden A, et al · · 2023 · cited 10× · PMID 37264471 · DOI 10.1186/s13054-023-04508-4
2. Feasibility of ICU mobilisation within the first 48-72 hours: A multi-centre point prevalence study of mobility practices in the United Kingdom
   Black C, Sanger H, Battle C, Eden A, et al · · 2023 · DOI 10.21203/rs.3.rs-2713559/v1