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NCT05239286
Conventional Fluid Management vs Plethysmographic Variability Index -Based Goal Directed Fluid Management
NA trial testing General anaesthesia in Fluid Management During Elective Spine Surgeries in 66 participants. Completed in 30 September 2022.
24 August 2022
Quick facts
| Lead sponsor | Cairo University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 66 |
| Start date | 24 January 2022 |
| Primary completion | 24 August 2022 |
| Estimated completion | 30 September 2022 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- General anaesthesia
- Conventional fluid managment — full drug profile →
- PVI dependant goal directed fluid therapy — full drug profile →
Conditions studied
- Fluid Management During Elective Spine Surgeries — all drugs for Fluid Management During Elective Spine Surgeries →
Sponsor
Cairo University
Who can join
Adults 18 to 65, any sex, with Fluid Management During Elective Spine Surgeries. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Plethysmographic variability index is a dynamic method for evaluation of volume status which depends on estimation of respiratory variations in pulse oximeter waveform amplitude. The PVI has been studied in various patient populations and clinical settings, and has been shown to reliably predict fluid responsiveness and guide fluid resuscitation. conventional fluid management. Fluid replacement is managed according to clinical assessment, heart rate, arterial blood pressure and central venous pressure monitoring. However, clinical studies indicate that changes in ABP cannot be used for the monitoring of stroke volume and cardiac output. Another method is the goal-directed fluid management and it is based on individualized fluid management using static and dynamic parameters.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Conventional fluid management versus plethysmographic variability index-based goal directed fluid management in patients undergoing spine surgery in the prone position - a randomised control trial.
Abdelhamid B, Matta M, Rady A, Adel G, et al · · 2023 · cited 4× · PMID 37728446 · DOI 10.5114/ait.2023.130792
Verify or expand the search:
- PubMed search for NCT05239286
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05239286 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Cairo University
- Last refreshed: 10 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05239286.
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