NCT03229148 (AMETIS) is a NA clinical trial of General anaesthesia in Stroke, sponsored by University Hospital, Clermont-Ferrand.

Who is sponsoring NCT03229148?

NCT03229148 is sponsored by University Hospital, Clermont-Ferrand.

What drugs are being tested in NCT03229148?

Interventions in NCT03229148: General anaesthesia, Conscious Sedation.

What condition does NCT03229148 study?

NCT03229148 studies Stroke, Thrombectomy, Anesthesia, Conscious Sedation.

Is NCT03229148 still recruiting?

NCT03229148 is currently completed. Last updated 30 September 2020.

Last reviewed 2020-09-30 · How we verify

NCT03229148: AMETIS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Anesthesia Management in Endovascular Therapy for Ischemic Stroke

Completed NA Last updated 30 September 2020

What this trial tests

NA trial testing General anaesthesia in Stroke in 332 participants. Completed in 30 June 2020.

Timeline

31 August 2017

Primary endpoint
13 May 2020

30 June 2020

Quick facts

Lead sponsor	University Hospital, Clermont-Ferrand
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	332
Start date	31 August 2017
Primary completion	13 May 2020
Estimated completion	30 June 2020
Sites	1 location across France

Drugs / interventions tested

General anaesthesia
Conscious Sedation — full drug profile →

Conditions studied

Stroke — all drugs for Stroke →
Thrombectomy — all drugs for Thrombectomy →
Anesthesia — all drugs for Anesthesia →
Conscious Sedation — all drugs for Conscious Sedation →

Sponsor

University Hospital, Clermont-Ferrand

Who can join

18 and older, any sex, with Stroke or Thrombectomy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Objective of the study: to assess whether pharmacological sedation or general anesthesia for treatment of anterior circulation ischemic stroke with endovascular mechanical thrombectomy is associated with difference in morbidity (neurological outcome and peri-procedural complications).

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

General Anesthesia Compared With Non-GA in Endovascular Thrombectomy for Ischemic Stroke: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Campbell D, Butler E, Campbell RB, Ho J, et al · · 2023 · cited 50× · PMID 36797071 · DOI 10.1212/wnl.0000000000207066
Outcomes After Endovascular Therapy With Procedural Sedation vs General Anesthesia in Patients With Acute Ischemic Stroke: The AMETIS Randomized Clinical Trial.
Chabanne R, Geeraerts T, Begard M, Balança B, et al · · 2023 · cited 45× · PMID 37010829 · DOI 10.1001/jamaneurol.2023.0413
Type of anaesthesia for acute ischaemic stroke endovascular treatment.
Tosello R, Riera R, Tosello G, Clezar CN, et al · · 2022 · cited 10× · PMID 35857365 · DOI 10.1002/14651858.cd013690.pub2
Sedation versus general anaesthesia in endovascular therapy for anterior circulation acute ischaemic stroke: the multicentre randomised controlled AMETIS trial study protocol.
Chabanne R, Fernandez-Canal C, Degos V, Lukaszewicz AC, et al · · 2019 · cited 6× · PMID 31519668 · DOI 10.1136/bmjopen-2018-027561
Effects of general anesthesia on short-term outcomes of patients with acute ischemic stroke after endovascular treatments: a meta-analysis.
Ye S, Mao M, Zhang Y. · · 2025 · PMID 41626022 · DOI 10.3389/fneur.2025.1728140
ESOC 2022 Abstract Book
· 2022
New paradigm shift in perioperative medicine: General anaesthesia finally better than procedural sedation for anterior circulation stroke thrombectomy?
Chabanne R, Begard M, Cazenave L, Pereira B. · · 2019 · PMID 31785703 · DOI 10.1016/j.accpm.2019.10.005

Verify or expand the search:

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Other recruiting trials for Stroke

Currently open trials in the same condition.

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NCT06704074 — Virtual Reality Task Oriented Training on Upper Limb Function in Stroke Patients · NA · recruiting

Other University Hospital, Clermont-Ferrand trials

Trials by the same sponsor.

NCT07179276 — Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock · NA · recruiting
NCT07476768 — PAINDYS_Characterizing Pain in Fibrous Dysplasia of Bone/McCune-Albright Syndrome: an Exploratory Pilot Study · NA · not yet recruiting
NCT07439146 — Risk of Pneumonia in Intubated Patients in Emergency Situations · not yet recruiting
NCT07427537 — Exploration of Circulating microRNAs as Biomarkers of Chemo-induced Peripheral Neuropathy: a Study in Cancer Patients · NA · recruiting
NCT07330856 — Evaluation of Treatments for Dry or Productive Cough · Phase 4 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03229148 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Clermont-Ferrand
Last refreshed: 30 September 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03229148.

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