Last reviewed · How we verify
NCT04206046
The Effect of Regional Anaesthesia and Genetic Factors in the Development of Chronic Pain Following Total Knee Arthroplasty
NA trial testing Spinal anaesthesia in Arthroplasty, Replacement, Knee in 200 participants. Status unknown.
1 June 2022
Quick facts
| Lead sponsor | Sciberras, Stephen M.D. |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 200 |
| Start date | 1 June 2017 |
| Primary completion | 1 June 2022 |
| Estimated completion | 30 December 2023 |
| Sites | 1 location across Malta |
Drugs / interventions tested
- Spinal anaesthesia
- General anaesthesia
Conditions studied
- Arthroplasty, Replacement, Knee — all drugs for Arthroplasty, Replacement, Knee →
- Chronic Pain Post-Proceduraal — all drugs for Chronic Pain Post-Proceduraal →
Sponsor
Sciberras, Stephen M.D.
Who can join
Adults 18 to 75, any sex, with Arthroplasty, Replacement, Knee or Chronic Pain Post-Proceduraal. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The study aims to assess the effect of spinal anaesthesia against a general anaesthesia with a femoral block, with respect to the incidence of chronic pain following a total knee replacement. It will also focus on genetic factors and their influence on chronic pain.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A randomized, controlled trial on the effect of anesthesia on chronic pain after total knee arthroplasty.
Sciberras SC, Vella AP, Vella B, Spiteri J, et al · · 2022 · cited 10× · PMID 35350864 · DOI 10.2217/pmt-2021-0081
Verify or expand the search:
- PubMed search for NCT04206046
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Spinal anaesthesia
Trials testing the same drug.
- NCT04631822 — Comparing Dexamethasone With Dexmedetomidine as Additives to Bupivacaine in Adductor Canal Block for Knee Arthroscopy. · NA · completed
- NCT04002271 — Total Knee Replacement TIVA With Robotic Arm Assisted · Phase 4 · unknown
- NCT03013140 — Preloading to Prevent Hypotension During Cesarean Section · NA · completed
Other recruiting trials for Arthroplasty, Replacement, Knee
Currently open trials in the same condition.
- NCT07337772 — Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty · NA · recruiting
- NCT07058623 — Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement · NA · recruiting
- NCT05992064 — Wearable Sensors for Monitoring Recovery After Total Knee Arthroplasty · recruiting
- NCT05518513 — Continuous Infusion and Intermittent Bolus Adductor Canal Block for Total Knee Arthroplasty · NA · recruiting
- NCT04884542 — Multigen Plus H Study and AMF TT Cones · recruiting
Other Sciberras, Stephen M.D. trials
Trials by the same sponsor.
- NCT05202769 — Non-Invasive Vital Signs Monitoring (NIVS) Project · unknown
- NCT05077982 — The Long Term Effects of COVID on Pulmonary Function · completed
- NCT05035589 — The Effect of Tocilizumab on Procalcitonin and Other Biochemical and Clinical Markers in the Setting of COVID-19 Pneumon · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04206046 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sciberras, Stephen M.D.
- Last refreshed: 26 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04206046.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing