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NCT05237414
Combining Cognitive Training With tDCS to Enhance Memory Inhibition in Young Binge Drinkers
NA trial testing Active tDCS in Binge Drinking in 114 participants. Completed in 15 August 2022.
5 May 2022
Quick facts
| Lead sponsor | University of Minho |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 114 |
| Start date | 5 February 2019 |
| Primary completion | 5 May 2022 |
| Estimated completion | 15 August 2022 |
| Sites | 1 location across Portugal |
Drugs / interventions tested
- Active tDCS
- Sham tDCS
- Active CT
- Sham CT
Conditions studied
- Binge Drinking — all drugs for Binge Drinking →
Sponsor
University of Minho
Who can join
Adults 18 to 24, any sex, with Binge Drinking. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study protocol aims to examine the behavioral and electroencephalographic (EEG) correlates of memory inhibition (MI) among college binge drinkers (BDs). A second objective is to evaluate an alcohol-specific MI training protocol using cognitive training (CT) and transcranial direct current stimulation (tDCS) while its effects on behavioral and EEG outcomes are assessed. Along with poor MI abilities, we hypothesized that BDs would show alterations in the amplitude of several event-related potentials (ERPs) linked to MI (e.g., N2 and late parietal positivity) as well as abnormal functional connectivity (FC) patterns within/between regions associated with MI (e.g., dorsolateral prefrontal cortex \[DLPFC\] and hippocampal/parahippocampal regions). Results should also demonstrate the effectiveness of the training protocol, with BDs exhibiting an improved capacity to suppress alcohol-related memories after both combined and cognitive MI training, along with a significant reduction in alcohol use and craving in the short/medium-term. Furthermore, this protocol should also lead to significant modifications in the ERP and FC patterns, reflecting stronger MI capabilities and reduced alcohol cue reactivity in trained BD participants.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Trying to forget alcohol: Brain mechanisms underlying memory suppression in young binge drinkers.
Almeida-Antunes N, Antón-Toro L, Crego A, Rodrigues R, et al · · 2024 · cited 4× · PMID 38871018 · DOI 10.1016/j.pnpbp.2024.111053 -
Forgetting Alcohol: A Double-Blind, Randomized Controlled Trial Investigating Memory Inhibition Training in Young Binge Drinkers.
Almeida-Antunes N, Vasconcelos M, Crego A, Rodrigues R, et al · · 2022 · cited 3× · PMID 35844233 · DOI 10.3389/fnins.2022.914213
Verify or expand the search:
- PubMed search for NCT05237414
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05237414 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Minho
- Last refreshed: 3 November 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05237414.
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