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NCT05236413
The Effect of a High Fiber Diet and High-Intensity Interval Exercise in Patients With HFpEF
NA trial testing High Intensity Interval Exercise in Heart Failure With Preserved Ejection Fraction in 36 participants. Currently enrolling.
1 August 2025
Quick facts
| Lead sponsor | University of Virginia |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | supportive care |
| Enrollment | 36 |
| Start date | 1 April 2022 |
| Primary completion | 1 August 2025 |
| Estimated completion | 1 August 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- High Intensity Interval Exercise
- Dietary Approaches to Stop Hypertension (DASH) Diet
- Exercise + DASH Diet
Conditions studied
- Heart Failure With Preserved Ejection Fraction — all drugs for Heart Failure With Preserved Ejection Fraction →
Sponsor
University of Virginia
Who can join
40 and older, any sex, with Heart Failure With Preserved Ejection Fraction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is trying to find out how best to improve common measures of health and survival in those diagnosed with heart failure with preserved ejection fraction (HFpEF) through the implementation of 4 weeks of an exercise training program consisting of high intensity interval training, dietary approaches to stop hypertension (DASH diet), or a combination of the two. Currently there are not established guidelines that have been shown to improve clinical end points in those with this HFpEF.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Lifestyle interventions in cardiometabolic HFpEF: dietary and exercise modalities.
Vacca A, Wang R, Nambiar N, Capone F, et al · · 2025 · cited 17× · PMID 39283525 · DOI 10.1007/s10741-024-10439-1 -
Dietary Interventions in Heart Failure With Preserved Ejection Fraction: A Scoping Review.
Billingsley HE, Carbone S, Driggin E, Kitzman DW, et al · · 2025 · cited 8× · PMID 39801812 · DOI 10.1016/j.jacadv.2024.101465 -
Nonpharmacological Strategies in Heart Failure with Preserved Ejection Fraction.
Bohmke NJ, Billingsley HE, Kirkman DL, Carbone S. · · 2022 · cited 8× · PMID 36210133 · DOI 10.1016/j.ccl.2022.06.003 -
Gut Microbiota and Short-Chain Fatty Acids in Cardiometabolic HFpEF: Mechanistic Pathways and Nutritional Therapeutic Perspectives.
Vacca A, Brosolo G, Marcante S, Della Mora S, et al · · 2026 · PMID 41599934 · DOI 10.3390/nu18020321
Verify or expand the search:
- PubMed search for NCT05236413
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of High Intensity Interval Exercise
Trials testing the same drug.
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- NCT04664205 — Isoenergetic High Intensity Interval Training and Moderate Intensity Training in Adults With Type I Diabetes · NA · completed
- NCT03036371 — Pilot Study of the Impact of Exercise on Hippocampal Function · NA · completed
Other recruiting trials for Heart Failure With Preserved Ejection Fraction
Currently open trials in the same condition.
- NCT06833138 — Atrioventricular Node Ablation and Conduction System Pacing in Patients With Well Controlled Permanent Atrial Fibrillati · NA · recruiting
- NCT06937827 — Transitions of Care Clinic (TOCC) · NA · recruiting
- NCT07037459 — Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity · Phase 3 · recruiting
- NCT06702501 — The PeriCut Catheter System Early Feasibility Study (REIMAGINE-HFpEF) · NA · recruiting
- NCT06616974 — A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction · Phase 2 · recruiting
Other University of Virginia trials
Trials by the same sponsor.
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- NCT07146685 — Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study · Phase 4 · not yet recruiting
- NCT07298941 — Resilience Enhancement Following Sleep Treatment · Phase 2 · recruiting
- NCT07036315 — Meaning in Music-Based Pain Modulation · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05236413 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Virginia
- Last refreshed: 7 May 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05236413.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing