NCT05206266

Bioenhancing Effects of Black Pepper With Turmeric on Pain Ratings

Completed NA Last updated 5 July 2023

What this trial tests

NA trial testing Turmeric in Pain in 30 participants. Completed in 16 June 2023.

Timeline

13 February 2022

Primary endpoint
30 May 2023

16 June 2023

Quick facts

Lead sponsor	University of Alabama at Birmingham
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	30
Start date	13 February 2022
Primary completion	30 May 2023
Estimated completion	16 June 2023
Sites	1 location across United States

Drugs / interventions tested

• Turmeric — full drug profile →
• Turmeric+Black Pepper

Conditions studied

• Pain — all drugs for Pain →

Sponsor

University of Alabama at Birmingham

Who can join

40 and older, any sex, with Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Although multiple clinical trials have been reported studying the effects of turmeric and turmeric-derived curcuminoid containing extract on pain by various study designs (including both acute and chronic pain), with the most consistent positive pain reduction benefits at turmeric or curcuminoid levels above normal dietary intake estimates, studies assessing the combination of black pepper and turmeric at culinary relevant levels for pain remediation benefits are needed. As black pepper is reported to 'enhance' the effects of co-consumed compounds, we are testing whether consumption of black pepper alters the pain alleviating effects of turmeric when consumed at levels representative of potential dietary intakes.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Bioenhancer Assessment of Black Pepper with Turmeric on Self-Reported Pain Ratings in Adults: A Randomized, Cross-Over, Clinical Trial.
   Durham L, Oster RA, Ithurburn M, Reynolds C, et al · · 2026 · PMID 41599836 · DOI 10.3390/nu18020223