NCT04922229 is a NA clinical trial of RCT in Irreversible Pulpitis, sponsored by University of Alabama at Birmingham.

Who is sponsoring NCT04922229?

NCT04922229 is sponsored by University of Alabama at Birmingham.

What drugs are being tested in NCT04922229?

Interventions in NCT04922229: RCT, Pulpotomy.

What condition does NCT04922229 study?

NCT04922229 studies Irreversible Pulpitis.

Is NCT04922229 still recruiting?

NCT04922229 is currently not yet recruiting. Last updated 17 February 2026.

Last reviewed 2026-02-17 · How we verify

NCT04922229

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparative Effectiveness in the Management of Irreversible Pulpitis

Not yet recruiting NA Last updated 17 February 2026

What this trial tests

NA trial testing RCT in Irreversible Pulpitis in 138 participants. Not yet recruiting.

Timeline

1 June 2027

Primary endpoint
30 June 2030

31 December 2031

Quick facts

Lead sponsor	University of Alabama at Birmingham
Phase	NA
Status	Not yet recruiting
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	138
Start date	1 June 2027
Primary completion	30 June 2030
Estimated completion	31 December 2031
Sites	1 location across United States

Drugs / interventions tested

RCT
Pulpotomy

Conditions studied

Irreversible Pulpitis — all drugs for Irreversible Pulpitis →

Sponsor

University of Alabama at Birmingham

Who can join

Adults 12 to 99, any sex, with Irreversible Pulpitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This project addresses a central question within the practice of dentistry: Is a pulpotomy procedure effective in the treatment of a tooth with symptomatic irreversible pulpitis and normal periapex? In addition, the project seeks to identify clinical and molecular biomarkers that are predictive of the success of pulpotomy.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Minimally invasive endodontics: a new era for pulpotomy in mature permanent teeth.
Philip N, Suneja B. · · 2022 · cited 31× · PMID 36526777 · DOI 10.1038/s41415-022-5316-1
Effectiveness of full Pulpotomy compared with Root canal treatment in managing teeth with signs and symptOms indicative of irreversible pulpitis: a protocol for prospectiVE meta-analysis of individual participant data of linked randomised clinical trials (PROVE).
El Karim IA, Duncan HF, Fouad AF, Taha NA, et al · · 2023 · cited 4× · PMID 38102685 · DOI 10.1186/s13063-023-07836-6

Verify or expand the search:

Other recruiting trials for Irreversible Pulpitis

Currently open trials in the same condition.

NCT07233564 — Comparison of Pain Between Supraperiosteal Injection of Dexamethasone Versus Placebo on Postoperative Pain in Teeth With · NA · active not recruiting
NCT06843525 — Bite Force Measurements · recruiting
NCT07163975 — Complete Pulpotomy and Root Canal Treatment Patients With Irreversible Pulpitis With Type 2 Diabetes Mellitus · NA · recruiting
NCT07073573 — Evaluation of Pulpal Biomarkers in Vital Pulp Therapy · NA · active not recruiting
NCT06730360 — Clinical and Radiographic Assessment of Photobiomodulated MTA Pulpotomy in Immature First Permanent Molars with Irrevers · NA · recruiting

Other University of Alabama at Birmingham trials

Trials by the same sponsor.

NCT05060380 — Feasibility of a Novel Resistance Exercise in Individuals With Osteoporosis · NA · withdrawn
NCT07564934 — Leveraging Extended Reality Exergaming and Telehealth to Improve Physical Activity and Health in Children With Disabilit · Phase 2 · not yet recruiting
NCT06320951 — VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine · Phase 2 · not yet recruiting
NCT04768777 — Behavioral Intervention for Physical Activity and Sexual Dysfunction in Multiple Sclerosis · NA · not yet recruiting
NCT07457385 — Congenital Syphilis Treatment Trial (CONSISTENT) in Neonates · Phase 4 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04922229 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Alabama at Birmingham
Last refreshed: 17 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04922229.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing