Last reviewed · How we verify
NCT05062629
United States Hypophosphatasia Molecular Research Center
trial testing Whole Genome Sequencing in Hypophosphatasia in 66 participants. Participants enrolled and being followed up; not accepting new ones.
30 April 2026
Quick facts
| Lead sponsor | Children's Mercy Hospital Kansas City |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 66 |
| Start date | 24 August 2021 |
| Primary completion | 30 April 2026 |
| Estimated completion | 30 June 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Whole Genome Sequencing
Conditions studied
- Hypophosphatasia — all drugs for Hypophosphatasia →
Sponsor
Children's Mercy Hospital Kansas City
Who can join
Eligibility, any sex, with Hypophosphatasia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is being done to determine if cryptic alterations exist within or near to the ALPL gene in patients with a clinical diagnosis of hypophosphatasia, but without identifiable alteration on commercial testing. Additionally, the study aims to characterize functional effects of certain variants of uncertain significance in patients with clinical diagnosis of hypophosphatasia.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05062629
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Whole Genome Sequencing
Trials testing the same drug.
- NCT06535542 — Integrating Whole Genome Sequencing and Digital Twins Into the Management of Hypercholesterolemia in Emiratis · NA · recruiting
- NCT06399952 — Baker Gordon Syndrome Natural History Study · recruiting
- NCT05071859 — Genetic Overlap Between Anomalies and Cancer in Kids in the Children's Oncology Group: The COG GOBACK Study · active not recruiting
- NCT03911531 — Whole Exome Sequencing and Whole Genome Sequencing for Nonimmune Fetal/Neonatal Hydrops · recruiting
- NCT03709862 — Global Syphilis Sequencing · completed
Other recruiting trials for Hypophosphatasia
Currently open trials in the same condition.
- NCT07390240 — The Effect of Monoallelic Variants in the ALPL Gene on the Natural Course of Hypophosphatasia in Russia · recruiting
- NCT06079359 — Phase 3 Study of ALXN1850 in Treatment-Naïve Pediatric Participants With HPP · Phase 3 · active not recruiting
- NCT06079372 — Phase 3 Study of ALXN1850 in Pediatric Participants With HPP Previously Treated With Asfotase Alfa · Phase 3 · active not recruiting
- NCT06079281 — Phase 3 Study of ALXN1850 Versus Placebo in Adolescent and Adult Participants With HPP Who Have Not Previously Been Trea · Phase 3 · active not recruiting
- NCT05234567 — A Prospective Sub-Study of the Global Hypophosphatasia Registry · recruiting
Other Children's Mercy Hospital Kansas City trials
Trials by the same sponsor.
- NCT07458568 — ViBandz Feasibility Study · not yet recruiting
- NCT07195032 — Safety and Efficacy of Measles, Mumps, Rubella Vaccination in Pediatric Heart Transplantation Patients · Phase 4 · recruiting
- NCT06834594 — Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome · Phase 4 · recruiting
- NCT06738121 — Cosmetic Outcomes of Umbilical Hernia Incisions · NA · completed
- NCT06520657 — Addressing Social Determinants of Health in Child Obesity Treatment Using Community Health Workers · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05062629 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Children's Mercy Hospital Kansas City
- Last refreshed: 14 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05062629.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing