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NCT03709862
Global Syphilis Sequencing
trial testing Whole Genome Sequencing in Syphilis in 726 participants. Completed in 28 February 2022.
31 December 2020
Quick facts
| Lead sponsor | London School of Hygiene and Tropical Medicine |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 726 |
| Start date | 8 October 2018 |
| Primary completion | 31 December 2020 |
| Estimated completion | 28 February 2022 |
| Sites | 5 locations across United Kingdom |
Drugs / interventions tested
- Whole Genome Sequencing
Conditions studied
- Syphilis — all drugs for Syphilis →
Sponsor
London School of Hygiene and Tropical Medicine
Who can join
18 and older, any sex, with Syphilis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Syphilis is an important sexually transmitted infection. There has been an epidemic of syphilis amongst men who have sex with men in the United Kingdom in the last decade. Early infection with syphilis causes a genital ulcer followed, in the absence of treatment, by a generalised illness often accompanied by rash. Studies on syphilis have been limited because it is not possible to grow syphilis outside of the body. New approaches allow the whole genetic sequence of Treponema pallidum to be obtained from a swab. In this study residual DNA collected as part of routine patient care of patients seen at sexual health clinics in the UK will be used for sequencing. No patient contact is involved in the study which is limited to whole genome sequencing using residual material from samples. By better understanding the genome of the T.pallidum insights will be gained in to the pathogenesis of this important sexually transmitted disease.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03709862
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Syphilis
Currently open trials in the same condition.
- NCT06738407 — Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections · Phase 4 · recruiting
- NCT07300254 — Treponemal Shedding, Load, and Viability, in Women and Men-who-have-sex-with-women-only With Early Infectious Syphilis: · recruiting
- NCT07150871 — Impact of Covid-19 on Syphilis · active not recruiting
- NCT06927843 — Investigational Study to Evaluate the DPP® Syphilis Screen & Confirm Antibody Point-of-care Test (POCT) to Diagnose Infe · active not recruiting
- NCT06683638 — Daily Doxycycline for Early Syphillis · Phase 2 · recruiting
Other London School of Hygiene and Tropical Medicine trials
Trials by the same sponsor.
- NCT06921213 — Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis · Phase 2 · not yet recruiting
- NCT06923592 — Serological Testing and Treatment for Plasmodium Vivax Malaria: a Trial in Ethiopia and Madagascar · Phase 3 · recruiting
- NCT06833736 — A Health App Using Recipes and Education Components to Facilitate Sustainable and Healthier Diets. · NA · completed
- NCT06166498 — Parasite Clearance and Protection From Infection (PCPI) in Zambia · Phase 3 · completed
- NCT06173206 — Parasite Clearance and Protection From Infection (PCPI) in Cameroon · Phase 3 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03709862 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by London School of Hygiene and Tropical Medicine
- Last refreshed: 12 April 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03709862.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing