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NCT04979793
Role of L-citrulline in Prevention of Pregnancy Associated Hypertension
Phase 1 trial testing L-citrulline in Pregnancy Induced Hypertension in 338 participants. Suspended.
30 July 2027
Quick facts
| Lead sponsor | The University of Texas Medical Branch, Galveston |
|---|---|
| Phase | Phase 1 |
| Status | Suspended |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 338 |
| Start date | 28 July 2021 |
| Primary completion | 30 July 2027 |
| Estimated completion | 30 July 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- L-citrulline (Citrulline) — full drug profile →
- Placebo
Conditions studied
- Pregnancy Induced Hypertension — all drugs for Pregnancy Induced Hypertension →
- Preeclampsia and Eclampsia — all drugs for Preeclampsia and Eclampsia →
- Gestational Hypertension — all drugs for Gestational Hypertension →
Sponsor
The University of Texas Medical Branch, Galveston
Who can join
18 and older, female only, with Pregnancy Induced Hypertension or Preeclampsia and Eclampsia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The target population for our study is healthy nulliparous pregnant women (first pregnancy) between the 12-16 week of pregnancy. If a subject is eligible, written consent will be obtained by person to person contact. Eligible participants will be randomized to receive either daily L-citrulline supplementation or placebo.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
New Ideas for the Prevention and Treatment of Preeclampsia and Their Molecular Inspirations.
Sakowicz A, Bralewska M, Rybak-Krzyszkowska M, Grzesiak M, et al · · 2023 · cited 28× · PMID 37569476 · DOI 10.3390/ijms241512100
Verify or expand the search:
- PubMed search for NCT04979793
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of L-citrulline
Trials testing the same drug.
- NCT06426147 — L-citrulline to Improve Adverse Outcomes in Admitted Children (EChiLiBRiST, Clinical Trial 2, Inpatients) · NA · recruiting
- NCT06212765 — Oral Citrulline Supplementation in COPD Patients With Malnutrition · Phase 3 · not yet recruiting
- NCT05934318 — L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE) · NA · recruiting
- NCT06016478 — The Effect of 4 Weeks of L-Citrulline Supplementation on Macro- and Microvascular Function in Type 2 Diabetes · NA · completed
- NCT05778266 — Effect of L-citrulline and HIIT on Arterial Stiffness, Body Composition, and Lipid Profile in Adolescents with Steatosis · NA · completed
Other recruiting trials for Pregnancy Induced Hypertension
Currently open trials in the same condition.
- NCT06963528 — Gestational Diabetes Monitoring and Management · active not recruiting
- NCT05009433 — HIIT vs MICT During Pregnancy and Health and Birth Outcomes in Mothers and Children · NA · recruiting
- NCT04286217 — SD-OCT Measurement of the Human Retina in Pregnancy With Pre-existing or De Novo Hypertension and Without Hypertension · active not recruiting
Other The University of Texas Medical Branch, Galveston trials
Trials by the same sponsor.
- NCT04095260 — Identification of Neuromusculoskeletal Variables Associated With Injury Risk and Performance in High School Athletes. · not yet recruiting
- NCT06800092 — Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment · Phase 2, PHASE3 · not yet recruiting
- NCT07337915 — Improving Sleep In Midlife Women · NA · recruiting
- NCT07203287 — Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease · Phase 4 · recruiting
- NCT07087743 — Virtual Reality-Integrated Propulsion Feedback for Stroke Rehab · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04979793 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The University of Texas Medical Branch, Galveston
- Last refreshed: 19 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04979793.
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