What is L-Citrulline used for?

L-Citrulline is indicated for Circulation support, Fatigue relief.

Who makes L-Citrulline?

L-Citrulline is developed by Nantes University Hospital.

What development phase is L-Citrulline in?

L-Citrulline is FDA-approved (marketed).

What is the generic name of L-Citrulline?

Citrulline is the generic (nonproprietary) name of L-Citrulline.

Last reviewed 2026-04-20 · How we verify

L-Citrulline (Citrulline)

Nantes University Hospital · FDA-approved active Small molecule Quality 13/100

At a glance

Generic name	Citrulline
Sponsor	Nantes University Hospital
Drug class	Standardized Chemical Allergen [EPC]
Modality	Small molecule
Therapeutic area	Hematology
Phase	FDA-approved

Approved indications

Circulation support
Fatigue relief

Common side effects

No common side effects on file.

Key clinical trials

Effect of a Daily Supplement on Plasma PAI-1 Levels (PHASE1,PHASE2)
L-Citrulline and Endothelial Function (PHASE1)
COMP-4 Supplementation and Brachial Artery FMD (PHASE1,PHASE2)
L-citrulline to Improve Adverse Outcomes in Admitted Children (EChiLiBRiST, Clinical Trial 2, Inpatients) (NA)
Effect of NO Precursors on Physiological Responses to Exercise (NA)
Effect of Watermelon on Gut and Cardiometabolic Health (NA)
Effect of Citrulline Malate Supplementation on Physical Function and Biochemical Parameters in Physically Active Older Women (NA)
CHF COPD Sip Feed Anabolic Response (NA)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
ClinicalTrials.gov	Trial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

L-Citrulline CI brief — competitive landscape report
L-Citrulline updates RSS · CI watch RSS
Nantes University Hospital portfolio CI