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NCT05778266
Effect of L-citrulline and HIIT on Arterial Stiffness, Body Composition, and Lipid Profile in Adolescents with Steatosis Associated with Metabolic Dysfunction (MASLD)
NA trial testing L-citrulline in Metabolic Dysfunction-Associated Fatty Liver Disease in 43 participants. Completed in 30 April 2024.
15 January 2024
Quick facts
| Lead sponsor | Universidad de Guanajuato |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 43 |
| Start date | 14 March 2023 |
| Primary completion | 15 January 2024 |
| Estimated completion | 30 April 2024 |
| Sites | 1 location across Mexico |
Drugs / interventions tested
- L-citrulline (Citrulline) — full drug profile →
- Carboxymethyl cellulose
- High Intensity Intervals Training
Conditions studied
- Metabolic Dysfunction-Associated Fatty Liver Disease — all drugs for Metabolic Dysfunction-Associated Fatty Liver Disease →
- Obesity, Adolescent — all drugs for Obesity, Adolescent →
- Arterial Stiffness — all drugs for Arterial Stiffness →
Sponsor
Universidad de Guanajuato — full company profile →
Who can join
Adults 15 to 19, any sex, with Metabolic Dysfunction-Associated Fatty Liver Disease or Obesity, Adolescent. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) accelerate the appearance of arterial stiffness due to inflammatory and oxidative stress mechanisms producing increased vascular tone and increasing the risk of cardiovascular disease. This arterial stiffness can be measured through pulse wave velocity (PWV). Obesity and MAFLD have multifactorial components, high fructose diet and sedentary lifestyle are causing the onset of these diseases earlier in life such as in adolescence. L-citrulline, a non-protein amino acid, has shown positive effects on improving nitric oxide synthesis which improves endothelial function, as well as results on the metabolic profile in MASLD. High intensity interval training (HIIT) has also shown benefits on endothelial function improving the metabolic profile of people with obesity and MASLD with the advantage of decreasing the time required to perform the physical activity. A clinical study will be conducted with 45 adolescents (15-19 years old) with MASLD and the participants will be divided into 3 groups to perform HIIT and supplement with citrulline or placebo for 12 weeks.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Impact of L-Citrulline Supplementation and HIIT on Lipid Profile, Arterial Stiffness, and Fat Mass in Obese Adolescents with Metabolic-Dysfunction-Associated Fatty Liver Disease: A Randomized Clinical Trial.
Rodríguez-Carrillo AA, Espinoza-Vargas MR, Vargas-Ortiz K, Ibarra-Reynoso LDR, et al · · 2025 · cited 3× · PMID 39940261 · DOI 10.3390/nu17030402
Verify or expand the search:
- PubMed search for NCT05778266
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT06212765 — Oral Citrulline Supplementation in COPD Patients With Malnutrition · Phase 3 · not yet recruiting
- NCT05934318 — L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE) · NA · recruiting
- NCT06016478 — The Effect of 4 Weeks of L-Citrulline Supplementation on Macro- and Microvascular Function in Type 2 Diabetes · NA · completed
- NCT05253209 — A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Inju · Phase 3 · terminated
Other recruiting trials for Metabolic Dysfunction-Associated Fatty Liver Disease
Currently open trials in the same condition.
- NCT06739330 — Thyroid Dysfunction and Its Association With Metabolic Dysfunction-Associated Fatty Liver Disease · recruiting
- NCT06537882 — Evaluate the Effect of Synbiotics on MAFLD · NA · active not recruiting
Other Universidad de Guanajuato trials
Trials by the same sponsor.
- NCT06788054 — Intradialysis Exercise Functional Capacity, Body Composition and Survival in Hemodialysis Patients · NA · enrolling by invitation
- NCT06667180 — Effects of Low-intensity Transcranial Magnetic Stimulation on Major Depressive Disorder, and on 5-hydroxyindoleacetic Ac · Phase 1, PHASE2 · recruiting
- NCT05162001 — Body Weight Response With Disulfiram in Humans · EARLY_PHASE1 · unknown
- NCT04871360 — Effect of L-Citrulline Supplementation on NAFLD in Adolescents With Obesity · NA · completed
- NCT04636450 — Manual and Rotatory Instrumentation Pulpectomy in Primary Mandibular Molars · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05778266 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universidad de Guanajuato
- Last refreshed: 20 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05778266.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing