NCT04977076 (SLIM-2) is a NA clinical trial of Uninterrupted NOAC use in Atrial Fibrillation, sponsored by Zuyderland Medisch Centrum.

Who is sponsoring NCT04977076?

NCT04977076 is sponsored by Zuyderland Medisch Centrum.

What drugs are being tested in NCT04977076?

Interventions in NCT04977076: Uninterrupted NOAC use, Interrupted NOAC use.

What condition does NCT04977076 study?

NCT04977076 studies Atrial Fibrillation, Coronary Artery Disease, Anticoagulants.

Is NCT04977076 still recruiting?

NCT04977076 is currently status unknown. Last updated 26 July 2021.

Last reviewed 2021-07-26 · How we verify

NCT04977076: SLIM-2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison Between Direct Oral Anticoagulation (DOAC) Interruption and DOAC Continuation in Patients Undergoing Elective Invasive Coronary Angiography or Percutaneous Coronary Intervention

Status unknown NA Last updated 26 July 2021

What this trial tests

NA trial testing Uninterrupted NOAC use in Atrial Fibrillation in 1,214 participants. Status unknown.

Timeline

1 October 2021

Primary endpoint
31 December 2023

31 December 2023

Quick facts

Lead sponsor	Zuyderland Medisch Centrum
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	1,214
Start date	1 October 2021
Primary completion	31 December 2023
Estimated completion	31 December 2023

Drugs / interventions tested

Uninterrupted NOAC use
Interrupted NOAC use

Conditions studied

Atrial Fibrillation — all drugs for Atrial Fibrillation →
Coronary Artery Disease — all drugs for Coronary Artery Disease →
Anticoagulants — all drugs for Anticoagulants →

Sponsor

Zuyderland Medisch Centrum — full company profile →

Who can join

18 and older, any sex, with Atrial Fibrillation or Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A prospective, multicenter, 1:1 randomized, investigator initiated study. Goal of this study is to examine the safety of uninterrupted periprocedural NOAC use.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Direct oral anticoagulation interruption vs continuation in patients undergoing elective invasive coronary angiography or percutaneous coronary intervention: Design and rationale of the South Limburg Myocardial Infarction Study Group Trial 2 (SLIM-2).
Janssen S, Luijkx JJP, Swinnen W, Vriesendorp P, et al · · 2026 · PMID 42055156 · DOI 10.1016/j.ahj.2026.107462

Verify or expand the search:

Other recruiting trials for Atrial Fibrillation

Currently open trials in the same condition.

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Other Zuyderland Medisch Centrum trials

Trials by the same sponsor.

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NCT06827834 — Spinal Cord Monitoring in Multiple Sclerosis · recruiting
NCT06381518 — Switching From Intravenous to Subcutaneous Infliximab in Adult Patients With Inflammatory Bowel Disease · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04977076 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Zuyderland Medisch Centrum
Last refreshed: 26 July 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04977076.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing