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NCT06219018: HoneyForCINII
Effect of Honey For CIN II
Phase 1, PHASE2 trial testing Medical grade honey formulation (MGH) (L-Mesitran®) in Cervical Intraepithelial Neoplasia-II in 60 participants. Currently enrolling.
1 December 2026
Quick facts
| Lead sponsor | Zuyderland Medisch Centrum |
|---|---|
| Phase | Phase 1, PHASE2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 30 December 2024 |
| Primary completion | 1 December 2026 |
| Estimated completion | 1 December 2027 |
| Sites | 2 locations across Netherlands |
Drugs / interventions tested
- Medical grade honey formulation (MGH) (L-Mesitran®) — full drug profile →
Conditions studied
- Cervical Intraepithelial Neoplasia-II — all drugs for Cervical Intraepithelial Neoplasia-II →
- High Risk Human Papillomavirus — all drugs for High Risk Human Papillomavirus →
Sponsor
Zuyderland Medisch Centrum — full company profile →
Who can join
Adults 18 to 40, female only, with Cervical Intraepithelial Neoplasia-II or High Risk Human Papillomavirus. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The following hypothesis is tested: Medical grade honey in CIN II causes a higher clearance of the hr-HPV virus and an increase in the normalization of CIN II lesions compared to expectant management.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of medical-grade honey (L-Mesitran) for cervical intraepithelial neoplasia II: protocol for a multicentre cohort pilot study (HONEY FOR CIN II study).
Prop J, De Vos van Steenwijk P, Lardenoije CMJG, Cremers NAJ, et al · · 2025 · PMID 40707147 · DOI 10.1136/bmjopen-2025-104585
Verify or expand the search:
- PubMed search for NCT06219018
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06219018 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Zuyderland Medisch Centrum
- Last refreshed: 18 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06219018.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing