NCT07428967 (AVA CONDUCT) is a NA clinical trial of RV pacing in Atrial Fibrillation, sponsored by St. Josefs-Hospital Wiesbaden GmbH.

Who is sponsoring NCT07428967?

NCT07428967 is sponsored by St. Josefs-Hospital Wiesbaden GmbH.

What drugs are being tested in NCT07428967?

Interventions in NCT07428967: RV pacing, LBBA pacing.

What condition does NCT07428967 study?

NCT07428967 studies Atrial Fibrillation, Atrial Arrhythmia.

Is NCT07428967 still recruiting?

NCT07428967 is currently recruiting now. Last updated 24 February 2026.

Last reviewed 2026-02-24 · How we verify

NCT07428967: AVA CONDUCT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

AV Node Ablation and CONDUCTion System Pacing for Atrial Fibrillation With Preserved Left Ventricular Function

Recruiting now NA Last updated 24 February 2026

What this trial tests

NA trial testing RV pacing in Atrial Fibrillation in 86 participants. Currently enrolling.

Timeline

1 February 2026

Primary endpoint
31 December 2028

31 December 2029

Quick facts

Lead sponsor	St. Josefs-Hospital Wiesbaden GmbH
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	86
Start date	1 February 2026
Primary completion	31 December 2028
Estimated completion	31 December 2029
Sites	2 locations across Germany

Drugs / interventions tested

RV pacing
LBBA pacing

Conditions studied

Atrial Fibrillation — all drugs for Atrial Fibrillation →
Atrial Arrhythmia — all drugs for Atrial Arrhythmia →

Sponsor

St. Josefs-Hospital Wiesbaden GmbH

Who can join

18 and older, any sex, with Atrial Fibrillation or Atrial Arrhythmia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

AVA CONDUCT is a prospective, multicenter, randomized study with single blinding, comparing left bundle branch area (LBBA) pacing with right ventricular (RV) pacing following AV node ablation in terms of clinical, functional, and electrophysiological outcomes. The primary hypothesis is that pacing-induced cardiomyopathy, defined as a decrease in LVEF by 10% or more from baseline to an absolute value below 50%, occurs significantly more frequently in patients receiving RV pacing compared with LBBA pacing. Secondarily, LBBA pacing is expected to maintain comparable procedural safety while providing better cardiac function, resulting in improved quality of life and functional capacity compared with conventional RV pacing.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Atrial Fibrillation

Currently open trials in the same condition.

NCT07429214 — A Study of VARIPULSE Catheter and TRUPULSE Generator With VARIPULSE Pro Software in Participants With PAF or PsAF · NA · recruiting
NCT07271238 — Feasibility Study on the VERAFEYE Imaging and Navigation System for Guided Catheter Ablation Procedures · NA · recruiting
NCT07388108 — Atrial Dyssynchrony to Predict Arrhythmias in the Postoperative Setting of Cardiovascular Surgery. · recruiting
NCT06650995 — AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure · NA · recruiting
NCT07210151 — Anatomical Navigation for Guided Electrophysiology in AFL and AFib · NA · recruiting

Other St. Josefs-Hospital Wiesbaden GmbH trials

Trials by the same sponsor.

NCT07181291 — Pulsed Field or Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation in Heart Failure · completed
NCT05342220 — Effect of Ischemic Preconditioning on Atrial Fibrillation After Electrocardioversion · NA · completed
NCT04906668 — ABLATE Versus PACE: PVI or AV Node Ablation and PM Implantation for Elderly Patients With Persistent AF · NA · active not recruiting
NCT04587947 — Influence of Sacubitril/Valsartan on Autonomic Cardiac Nervous System in Heart Failure Patients: an Exploratory Study · NA · completed
NCT04655066 — Evaluation of the Subjectively Perceived Pelvic Floor Function in Patients With Gynecological Tumors and Breast Cancer U · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07428967 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by St. Josefs-Hospital Wiesbaden GmbH
Last refreshed: 24 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07428967.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing