Who is sponsoring NCT04967560?

NCT04967560 is sponsored by Shanghai Mental Health Center.

What drugs are being tested in NCT04967560?

Interventions in NCT04967560: deep brain stimulation.

What condition does NCT04967560 study?

NCT04967560 studies Obsessive-Compulsive Disorder.

Is NCT04967560 still recruiting?

NCT04967560 is currently completed. Last updated 18 May 2025.

Last reviewed 2025-05-18 · How we verify

NCT04967560

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Efficacy and Safety of ALIC/NAcc-DBS for Treatment-refractory OCD

Completed NA Last updated 18 May 2025

What this trial tests

NA trial testing deep brain stimulation in Obsessive-Compulsive Disorder in 60 participants. Completed in 29 January 2024.

Timeline

30 July 2021

Primary endpoint
13 November 2023

29 January 2024

Quick facts

Lead sponsor	Shanghai Mental Health Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	60
Start date	30 July 2021
Primary completion	13 November 2023
Estimated completion	29 January 2024
Sites	7 locations across China

Drugs / interventions tested

deep brain stimulation

Conditions studied

Obsessive-Compulsive Disorder — all drugs for Obsessive-Compulsive Disorder →

Sponsor

Shanghai Mental Health Center — full company profile →

Who can join

Adults 18 to 65, any sex, with Obsessive-Compulsive Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The present study aims to explore the efficacy and safety of DBS targeted the combination of the anterior limb of internal capsule and nucleus accumbens (ALIC/NAcc-DBS) to refractory OCD, based on multicenter, randomized, double-blinded, sham-stimulation controlled design, that could help to obtain stronger evidence of the efficacy of multiple targets.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Neuromodulation of OCD: A review of invasive and non-invasive methods.
Kammen A, Cavaleri J, Lam J, Frank AC, et al · · 2022 · cited 18× · PMID 36016538 · DOI 10.3389/fneur.2022.909264
Deep Brain Stimulation for the Management of Refractory Neurological Disorders: A Comprehensive Review.
Rissardo JP, Vora NM, Tariq I, Mujtaba A, et al · · 2023 · cited 17× · PMID 38004040 · DOI 10.3390/medicina59111991
The Efficacy and Safety of Deep Brain Stimulation of Combined Anterior Limb of Internal Capsule and Nucleus Accumbens (ALIC/NAcc-DBS) for Treatment-Refractory Obsessive-Compulsive Disorder: Protocol of a Multicenter, Randomized, and Double-Blinded Study.
Xu T, Gao Y, Li B, Jiang J, et al · · 2022 · cited 2× · PMID 35884739 · DOI 10.3390/brainsci12070933
Best practices for clinical trials of deep brain stimulation for neuropsychiatric indications.
Tremblay-McGaw AG, Hamlat EJ, Becker NC, Astudillo Maya DA, et al · · 2025 · cited 1× · PMID 40309667 · DOI 10.3389/fnhum.2025.1572972

Verify or expand the search:

Other trials of deep brain stimulation

Trials testing the same drug.

NCT07140302 — Surgery of Dystonia · NA · not yet recruiting
NCT06912282 — Bilateral Single-Electrode VO Combined With STN-DBS for Treating Meige Syndrome · NA · recruiting
NCT07031544 — Efficacy and Influencing Factors of ALIC-NAc Deep Brain Stimulation in Treatment-Refractory Obsessive-Compulsive Disorde · NA · recruiting
NCT06498934 — Deep Brain Stimulation of the Dentate Nucleus for Motor Rehabilitation After Stroke · NA · not yet recruiting
NCT06480188 — Differences in Brain Network Mechanisms Between STN and GPi Deep Brain Stimulation in the Treatment of Craniocervical Dy · NA · recruiting

Other recruiting trials for Obsessive-Compulsive Disorder

Currently open trials in the same condition.

NCT06575075 — Pilot Study of RR-HNK in OCD · Phase 1, PHASE2 · recruiting
NCT05783817 — MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study) · Phase 2 · recruiting
NCT07065669 — Treating Adolescent Obsessive Compulsive Disorder With Transcranial Magnetic Stimulation · NA · recruiting
NCT06376734 — Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness · Phase 2 · recruiting
NCT07000812 — EEG Evaluation of CBT for Obsessive-Compulsive Disorder · NA · active not recruiting

Other Shanghai Mental Health Center trials

Trials by the same sponsor.

NCT07480408 — Neural Mechanisms of the Sensorymotor Circuit in Sensory Phenomena in OCD · NA · not yet recruiting
NCT07479771 — tTIS Targeted of the Striatum as an Intervention for MUD Patients · NA · not yet recruiting
NCT07472673 — Transcranial Temporal Interference Stimulation Targeted of the Amygdala as an Intervention for Alcohol Use Disorder Pati · NA · not yet recruiting
NCT07484750 — Efficacy and Influencing Factors of Mindfulness-Based Exposure Group Therapy for OCD · NA · recruiting
NCT07311655 — Validation of the Accuracy of an AI-Based System for Diagnosing Anxiety Disorders · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04967560 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Shanghai Mental Health Center
Last refreshed: 18 May 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04967560.

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