NCT04951960

The Impact of Higher Positive End Expiratory Pressure on Patient-Ventilator Asynchrony

Status unknown NA Last updated 15 July 2021

What this trial tests

NA trial testing Higher PEEP setting in Critical Illness in 10 participants. Status unknown.

Timeline

1 November 2020

Primary endpoint
31 March 2022

31 March 2022

Quick facts

Lead sponsor	Osaka University
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	10
Start date	1 November 2020
Primary completion	31 March 2022
Estimated completion	31 March 2022
Sites	1 location across Japan

Drugs / interventions tested

• Higher PEEP setting
• Lower PEEP setting

Conditions studied

• Critical Illness — all drugs for Critical Illness →

Sponsor

Osaka University

Who can join

18 and older, any sex, with Critical Illness. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Patient-ventilator asynchrony is known to frequently occur during lung protective ventilation in patients with ARDS. Previous clinical studies showed that patient-ventilator asynchrony was associated with worse outcome in ICU. Therefore, strategies to reduce patient-ventilator asynchrony need to be established promptly. Several asynchronies, e.g., breath stacking are caused by vigorous spontaneous breathing effort. Recently, the investigators' group found that higher positive end expiratory pressure (PEEP) reduced the intensity of spontaneous breathing effort of in severe ARDS model (rabbits, pigs) and patients with ARDS. Thus, the investigators conjectured that higher PEEP may reduce the intensity of spontaneous breathing effort and thereby reduce patient-ventilator asynchrony during protective ventilation strategy, compared with lower PEEP in patients with ARDS.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.