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NCT04931784
Effect of Ultimaster Stents Treated to the Most Dilated Coronary Vessels
NA trial testing Nitrate in Vasodilation in 400 participants. Status unknown.
31 July 2023
Quick facts
| Lead sponsor | Inha University Hospital |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 400 |
| Start date | 1 August 2021 |
| Primary completion | 31 July 2023 |
| Estimated completion | 31 July 2024 |
Drugs / interventions tested
- Nitrate
Conditions studied
- Vasodilation — all drugs for Vasodilation →
- Coronary Artery Disease — all drugs for Coronary Artery Disease →
Sponsor
Inha University Hospital
Who can join
Adults 19 to 90, any sex, with Vasodilation or Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In patients with vasospasm or with negative remodeling, various vasodilator drugs used during coronary angiography can dilate the diameter of the reference vessel to measure the exact vessel size. In particular, nitrates are well known to induce pharmacological vasodilatory effects through vascular smooth muscle relaxation In actual clinical practice, it has been reported that when oral or spray-type nitrate preparations are administered to coronary artery stenosis lesions, the diameter of the reference vessel expands by about 10% compared to the existing vessel diameter. This may enable larger stenting in coronary artery stenosis lesions. Although many patients with vascular stenosis are accompanied by vasospasm and voice remodeling, in actual clinical practice, administration of vasodilators is only used in a small number of patients at the discretion of the surgeon. Nitrate vasodilators administered during coronary angiography are low-dose and short-acting drugs, and although a small number of patients may experience side effects such as short-term lowering of blood pressure, no serious side effects are reported . On this background, this study is to evaluate whether there is a difference in the diameter of the Ultimaster® stent treated with the conventional method compared to the maximally dilated coronary artery, and to evaluate the stability and effectiveness after the procedure.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A prospective double-blinded randomized study on drug-eluting stent implantation into nitrate-induced maximally dilated vessels in patients with coronary artery disease.
Yoon GS, Choi SH, Kwon SW, Park SD, et al · · 2023 · cited 1× · PMID 37464355 · DOI 10.1186/s13063-023-07497-5
Verify or expand the search:
- PubMed search for NCT04931784
- Europe PMC full search
- ASCO Meeting Library
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04931784 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Inha University Hospital
- Last refreshed: 18 June 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04931784.
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