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NCT05122689: DINE
Dietary Inorganic Nitrate and the Enteral Microbiome
NA trial testing Nitrate in Cardiovascular Health in 30 participants. Completed in 1 June 2024.
1 June 2024
Quick facts
| Lead sponsor | University Hospital, Essen |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | basic science |
| Enrollment | 30 |
| Start date | 22 November 2021 |
| Primary completion | 1 June 2024 |
| Estimated completion | 1 June 2024 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Nitrate
- Control
Conditions studied
- Cardiovascular Health — all drugs for Cardiovascular Health →
Sponsor
University Hospital, Essen
Who can join
Adults 40 to 80, any sex, with Cardiovascular Health. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A growing body of data shows that the enteral microbiome has an effect on cardiovascular diseases. Exogenous inorganic dietary nitrate mediates cardioprotective effects and has been shown to have an influence on the oral microbiome. The nutritional aspects of these cardioprotective effects are particularly intriguing since nitrate is abundant in our everyday diet. Whether dietary nitrate influences the enteral microbiome and downstream metabolites like short-chain fatty acids (SCFA) and TMAO will be investigated in the present study.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The influence of acute and chronic coronary syndrome on the gut microbiome and downstream microbiome-derived metabolites-Microbiome in acute myocardial infarction-MIAMI-Trial.
Messiha D, Lange E, Tratnik A, M Westendorf A, et al · · 2025 · PMID 40804540 · DOI 10.1007/s00395-025-01134-9
Verify or expand the search:
- PubMed search for NCT05122689
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Nitrate
Trials testing the same drug.
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- NCT06156618 — The Effect of Nitrate Supplement on the Oral Microbiome and Saliva in Dental Erosion · NA · unknown
- NCT04931784 — Effect of Ultimaster Stents Treated to the Most Dilated Coronary Vessels · NA · unknown
- NCT05143879 — Long-Term Effect of Combined Citrulline and Nitrate-Rich Beetroot Extract Supplementation · NA · completed
Other recruiting trials for Cardiovascular Health
Currently open trials in the same condition.
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- NCT03504059 — School-based Behavioural Intervention to Face Obesity and Promote Cardiovascular Health Among Spanish Adolescents · NA · active not recruiting
Other University Hospital, Essen trials
Trials by the same sponsor.
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- NCT07359690 — Multimodal Analysis of Endomyocardial Biopsies · recruiting
- NCT06388369 — Neoadjuvant Lu-PSMA Radioligand Therapy and Ipilimumab in Men With Very High-risk Prostate Cancer · Phase 1, PHASE2 · terminated
- NCT07130526 — Distrupt Stiffness Trial · NA · recruiting
- NCT07343466 — Quality of Life and the Influence of Stress on the Postoperative Course of Patients After Device Implantation · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05122689 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Essen
- Last refreshed: 25 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05122689.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing