NCT04857450 is a NA clinical trial of Etomidate in Anemia, sponsored by King Saud University.

Who is sponsoring NCT04857450?

NCT04857450 is sponsored by King Saud University.

What drugs are being tested in NCT04857450?

Interventions in NCT04857450: Etomidate, Ketamine Hydrochloride.

What condition does NCT04857450 study?

NCT04857450 studies Anemia, Cardiomyopathies, Pulmonary Hypertension.

Is NCT04857450 still recruiting?

NCT04857450 is currently status unknown. Last updated 23 April 2021.

Last reviewed 2021-04-23 · How we verify

NCT04857450

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Anesthesia for Upper Endoscopy and Colonoscopy in Cardiac Patients With Acute Anemia

Status unknown NA Last updated 23 April 2021

What this trial tests

NA trial testing Etomidate in Anemia in 60 participants. Status unknown.

Timeline

20 November 2020

Primary endpoint
20 November 2021

20 December 2021

Quick facts

Lead sponsor	King Saud University
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	supportive care
Enrollment	60
Start date	20 November 2020
Primary completion	20 November 2021
Estimated completion	20 December 2021
Sites	1 location across Saudi Arabia

Drugs / interventions tested

Etomidate (ETOMIDATE) — full drug profile →
Ketamine Hydrochloride — full drug profile →

Conditions studied

Anemia — all drugs for Anemia →
Cardiomyopathies — all drugs for Cardiomyopathies →
Pulmonary Hypertension — all drugs for Pulmonary Hypertension →

Sponsor

King Saud University

Who can join

Adults 18 to 65, any sex, with Anemia or Cardiomyopathies. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of this study was to try to reduce the required dose of etomidate used in anesthesia for upper endoscopy and colonoscopy in critically ill cardiac patients who complain of severe anemia in cardiac intensive care units by using a low dose of ketamine, which helps to reduce the side effects of etomidate, the most important of which is its suppressive effect on the adrenal gland and the secretion of cortisol in such critical cases, while maintaining hemodynamic stability, and the patient's satisfaction.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Effects of adding low-dose ketamine to etomidate on serum cortisol levels in critically ill cardiac patients: a randomized clinical trial.
Elhamamsy MM, Aldemerdash AM, Zahran FB, Ezz GFM, et al · · 2022 · cited 2× · PMID 35448950 · DOI 10.1186/s12871-022-01654-0
Effect of low-dose ketamine pretreatment to etomidate on serum cortisol levels in critically ill cardiac patients: A Randomized clinical trial
Elhamamsy M, Aldemerdash AM, Zahran FB, Ezz GFM, et al · · 2021 · DOI 10.21203/rs.3.rs-983661/v1

Verify or expand the search:

Other trials of Etomidate

Trials testing the same drug.

NCT04291521 — Prospective Study of Induction Medications Used in the Trauma RSI · not yet recruiting
NCT07012902 — Relationship Between Remimazolam and Etomidate in Induction of General Anesthesia · EARLY_PHASE1 · not yet recruiting
NCT06664138 — Comparison of Remimazolam and Etomidate As Induction Agents for Electroconvulsive Treatment · Phase 4 · completed
NCT05277896 — Randomized Trial of Sedative Choice for Intubation · Phase 4 · completed
NCT04934410 — Induction Agent and Incidence of Hypotension in Heart Failure Patients Undergoing LVAD-Implantation · unknown

Other recruiting trials for Anemia

Currently open trials in the same condition.

NCT07422480 — A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myel · Phase 3 · recruiting
NCT06968936 — Long-term Outcomes Sub-Study of Preoperative Combined Iron Therapy · NA · recruiting
NCT07328191 — Quality of Life-Guided Transfusion in Refractory MDS or AML · NA · recruiting
NCT07315295 — Maximizing the Benefits of Iron in Ready-to-Use Therapeutic Foods for Malnourished Children in Kenya · NA · recruiting
NCT07400796 — Assessing Health System Readiness for Scaling Antenatal MMS in Cambodia · recruiting

Other King Saud University trials

Trials by the same sponsor.

NCT07500493 — Tele-Rehabilitation in Adults With Cystic Fibrosis · NA · not yet recruiting
NCT07324044 — Chrono-ALIGN: A Chronotype-Based Chrono-Nutrition Intervention in Post-Bariatric Patients · NA · not yet recruiting
NCT07288385 — Investigating the Feasibility of Combining Virtual Reality and Bilateral Transcranial Direct Stimulation to Improve Uppe · NA · recruiting
NCT07475195 — Oral Probiotics and Denture Care in Saudi Arabia: Evaluating Knowledge, Practices, and the Future of Innovative Hygiene · completed
NCT07159152 — Effects of Coffee Versus Hibiscus Tea Consumption During Prolonged Sitting on Blood Pressure and Heart Rate · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04857450 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by King Saud University
Last refreshed: 23 April 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04857450.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing