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NCT04797949
Adherence to Universal Aspirin Compared to Screening Indicated Aspirin for Prevention of Preeclampsia
Phase 4 trial testing Low-dose aspirin in Medication Adherence. Withdrawn.
1 June 2022
Quick facts
| Lead sponsor | Women and Infants Hospital of Rhode Island |
|---|---|
| Phase | Phase 4 |
| Status | Withdrawn |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Start date | 3 March 2021 |
| Primary completion | 1 June 2022 |
| Estimated completion | 1 June 2022 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Low-dose aspirin
Conditions studied
- Medication Adherence — all drugs for Medication Adherence →
- Preeclampsia — all drugs for Preeclampsia →
Sponsor
Women and Infants Hospital of Rhode Island
Who can join
18 and older, female only, with Medication Adherence or Preeclampsia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
There are data showing that a majority of pregnant women may not be accurately identified as high risk through screening and therefore, not receiving prophylactic low dose aspirin as recommended. This leads to missing many patients who would benefit from aspirin administration. Aspirin is an effective, affordable and safe intervention and its universal use in pregnancy has been proposed as the answer to help mitigate risk of significant morbidity from preeclampsia. However, adherence to aspirin in women at low risk compared to those deemed at high risk of preeclampsia has never been studied. One of the arguments against universal aspirin administration is the concern that universal receipt would change the compliance in those at high risk although there are no data to support this concern. To address the lack of data on differences in adherence, our goal in this proposal is to assess whether there is a difference in adherence to low dose aspirin (81 mg) in women at high risk of preeclampsia as indicated by USPSTF risk algorithm when compared to those women randomized to universal use.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04797949
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Other recruiting trials for Medication Adherence
Currently open trials in the same condition.
- NCT07420634 — Multilevel Ecological and COM-B Determinants of Medication Adherence in Adults With Diabetes · recruiting
- NCT06876233 — Mobile Cued Adherence Therapy (mCAT) for Blood Pressure Medication · NA · recruiting
- NCT05624931 — Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa · NA · recruiting
- NCT06949774 — INcentives and ReMINDers to Improve Long-term Medication Adherence (INMIND) · NA · recruiting
- NCT06569290 — Refinement and Testing of Recruitment Methodology for Behavioral Medication Adherence Interventions Using Behavioral Sci · NA · active not recruiting
Other Women and Infants Hospital of Rhode Island trials
Trials by the same sponsor.
- NCT06930508 — Bringing Medicines for HIV Prevention to a Family Planning Clinic · NA · not yet recruiting
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- NCT07077707 — Prenatal Genetics Chatbot Trial: Prenatal GENEie · NA · not yet recruiting
- NCT07222852 — Cardiovascular Protection After Preeclampsia With Enalapril · Phase 3 · not yet recruiting
- NCT05861531 — Combined Oral Motor Stimulation and Language on Preterm Infant Feeding · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04797949 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Women and Infants Hospital of Rhode Island
- Last refreshed: 4 April 2025
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