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NCT07222852: CAPP-E
Cardiovascular Protection After Preeclampsia With Enalapril
Phase 3 trial testing Enalapril in Preeclampsia in 60 participants. Not yet recruiting.
15 October 2027
Quick facts
| Lead sponsor | Women and Infants Hospital of Rhode Island |
|---|---|
| Phase | Phase 3 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 15 November 2025 |
| Primary completion | 15 October 2027 |
| Estimated completion | 15 October 2027 |
Drugs / interventions tested
- Enalapril (enalapril) — full drug profile →
- Standard treatment
Conditions studied
- Preeclampsia — all drugs for Preeclampsia →
- Hypertensive Disorder of Pregnancy — all drugs for Hypertensive Disorder of Pregnancy →
- Hypertension — all drugs for Hypertension →
- Gestational Hypertension — all drugs for Gestational Hypertension →
Sponsor
Women and Infants Hospital of Rhode Island
Who can join
18 and older, female only, with Preeclampsia or Hypertensive Disorder of Pregnancy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to learn if postpartum women are willing to be randomized to different blood pressure medicines after delivery and how that affects blood pressure in women with hypertensive disorders of pregnancy.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07222852
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Enalapril
Trials testing the same drug.
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- NCT06788314 — A Study of Enalapril in Treatment of Venous Malformations · Phase 2 · recruiting
- NCT04853758 — Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF. · Phase 3 · recruiting
- NCT04484350 — Blood Pressure Management in Stroke Following Endovascular Treatment · Phase 2 · completed
- NCT04236258 — Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum Period · Phase 4 · completed
Other recruiting trials for Preeclampsia
Currently open trials in the same condition.
- NCT06953115 — Vagal Stimulation Therapy and Preeclampsia · NA · recruiting
- NCT06333652 — Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders · Phase 2 · recruiting
- NCT07282171 — A Study to Investigate the Safety, Pharmacodynamic and Pharmacokinetic Characteristics of CBP-4888 in Hospitalized Parti · Phase 1 · recruiting
- NCT07345845 — MR and Inflammation After Preeclampsia · EARLY_PHASE1 · active not recruiting
- NCT07041281 — Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories · Phase 2 · recruiting
Other Women and Infants Hospital of Rhode Island trials
Trials by the same sponsor.
- NCT06930508 — Bringing Medicines for HIV Prevention to a Family Planning Clinic · NA · not yet recruiting
- NCT07437131 — Community-Partnered Doula Support for Neonatal Intensive Care Unit Families · NA · recruiting
- NCT07077707 — Prenatal Genetics Chatbot Trial: Prenatal GENEie · NA · not yet recruiting
- NCT05861531 — Combined Oral Motor Stimulation and Language on Preterm Infant Feeding · NA · recruiting
- NCT06953271 — Methenamine Hippurate Following Intradetrusor OnabotulinumtoxinA Injection · Phase 4 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07222852 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Women and Infants Hospital of Rhode Island
- Last refreshed: 30 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07222852.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing