NCT06281665 (TAP) is a Phase 4 clinical trial of Low-dose aspirin in Hypertensive Disorder of Pregnancy, sponsored by Malamo Countouris.

Who is sponsoring NCT06281665?

NCT06281665 is sponsored by Malamo Countouris.

What drugs are being tested in NCT06281665?

Interventions in NCT06281665: Low-dose aspirin, Placebo.

What condition does NCT06281665 study?

NCT06281665 studies Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Hypertension, Eclampsia, Gestational Hypertension, Cardiovascular Diseases, Toxemia, Pregnancy Complications, Vascular Diseases, Hypertension, Pregnancy Induced, Hypertension;Pre-Eclamptic.

Is NCT06281665 still recruiting?

NCT06281665 is currently recruiting now. Last updated 5 February 2026.

Last reviewed 2026-02-05 · How we verify

NCT06281665: TAP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Treatment With Aspirin After Preeclampsia: TAP Trial

Recruiting now Phase 4 Last updated 5 February 2026

What this trial tests

Phase 4 trial testing Low-dose aspirin in Hypertensive Disorder of Pregnancy in 60 participants. Currently enrolling.

Timeline

29 May 2024

Primary endpoint
1 June 2026

1 June 2027

Quick facts

Lead sponsor	Malamo Countouris
Phase	Phase 4
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	other
Enrollment	60
Start date	29 May 2024
Primary completion	1 June 2026
Estimated completion	1 June 2027
Sites	1 location across United States

Drugs / interventions tested

Low-dose aspirin
Placebo

Conditions studied

Hypertensive Disorder of Pregnancy — all drugs for Hypertensive Disorder of Pregnancy →
Pre-Eclampsia — all drugs for Pre-Eclampsia →
Hypertension — all drugs for Hypertension →
Eclampsia — all drugs for Eclampsia →

Sponsor

Malamo Countouris

Who can join

Adults 18 to 55, female only, with Hypertensive Disorder of Pregnancy or Pre-Eclampsia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of this research project is to conduct a single-site pilot trial to assess the feasibility and effect of low-dose aspirin to augment vascular recovery in the immediate postpartum period after preeclampsia through two specific aims: 1) to pilot test the feasibility of conducting a randomized controlled trial of postpartum low dose aspirin vs. placebo, and 2) to assess the effect of postpartum aspirin on endothelial function and blood pressure. Our central hypothesis is that postpartum administration of low-dose aspirin following preeclampsia will be feasible, improve endothelial function, and lower BP at 6 months postpartum. Subjects will undergo 3 study visits involving BP measurements, blood draws, questionnaires, and/or microiontophoresis. Up to 60 adult subjects will be enrolled at Magee-Women's Hospital.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of Low-dose aspirin

Trials testing the same drug.

NCT07529262 — Can Aspirin Reduce the Risk of HCC in Cirrhosis: The AspiRe HCC Trial · Phase 3 · not yet recruiting
NCT06002490 — A Study to Evaluate P1101 in Japanese PV Patients · Phase 3 · completed
NCT07523841 — Non-surgical Periodontitis Treatment With Aspirin and Omega-3 · NA · active not recruiting
NCT05198960 — AVAJAK: Apixaban/Rivaroxaban Versus Aspirin for Primary Prevention of Thrombo-embolic Complications in JAK2V617F-positiv · Phase 3 · recruiting
NCT05089175 — The Investigation of the Prediction Model and Prevention Strategy of Serious Pregnancy Complications in Hypertensive Dis · unknown

Other recruiting trials for Hypertensive Disorder of Pregnancy

Currently open trials in the same condition.

NCT07405723 — Arm Position and Blood Pressure Measurement Accuracy During Pregnancy · NA · recruiting
NCT07204756 — HOPE-BP 2.0: Evaluating the Optimal Duration of Postpartum Remote Blood Pressure Monitoring · NA · recruiting
NCT06362356 — Microbial Metabolites and Outcomes of Pregnancy Study · active not recruiting
NCT05655936 — Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial · NA · recruiting
NCT05659173 — Vitamin D Deficiency With Selected Vitamin D Receptor Gene Polymorphism in Gestational Hypertension · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06281665 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Malamo Countouris
Last refreshed: 5 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06281665.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing