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NCT04777487
Evaluation of Biomarker Levels in Gingival Crevicular Fluid of Patients With Different Periodontal Diseases
NA trial testing GCF obtaining in Periodontal Diseases in 60 participants. Completed in 25 September 2019.
25 September 2019
Quick facts
| Lead sponsor | Izmir Katip Celebi University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 60 |
| Start date | 1 April 2019 |
| Primary completion | 25 September 2019 |
| Estimated completion | 25 September 2019 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- GCF obtaining
Conditions studied
- Periodontal Diseases — all drugs for Periodontal Diseases →
Sponsor
Izmir Katip Celebi University
Who can join
Adults 18 to 60, any sex, with Periodontal Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Objectives: The aim of this study is; detection of peptidyl arginine deiminase4 (PAD4), galectin-3 and tumor necrosis factor alpha (TNF-α) levels in gingival crevicular fluid (GCF) samples of periodontally healthy, gingivitis and periodontitis patients and the possible correlation between these values and clinical parameters of periodontal diseases. Materials and methods: Samples of GCF were obtained from 60systemically healthy non-smoker individuals with periodontitis (P, n=20), gingivitis(G, n=20) and healthy periodontium (S, n=20). Full-mouth clinical periodontal measurements including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), gingival index (GI) and plaque index (PI) were also recorded. Enzyme-linked immunosorbent assay (ELISA) was used to determine PAD4, galectin-3 and TNF-α levels in the biological samples.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04777487
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Related trials
Other trials of GCF obtaining
Trials testing the same drug.
- NCT05281796 — Evaluation of Galectin-3 Levels in GCF And Saliva of Patients With Different Periodontal Diseases · completed
- NCT05435131 — Evaluation of Biomarkers Levels in Gingival Crevicular Fluid, Saliva and Serum for Different Periodontal Diseases · NA · completed
Other recruiting trials for Periodontal Diseases
Currently open trials in the same condition.
- NCT07358104 — Efficacy of Camel Whey Protein and Camel Whey Protein Nanoparticles for Treating Intra-bony Periodontal Defects · NA · active not recruiting
- NCT07312045 — HALP Score, Blood-Based Inflammatory Indices, and Salivary MMP-8 in Periodontal Disease and Healing After Non-Surgical T · recruiting
- NCT07384221 — Periodontal Status and Disease Severity in Pemphigus Vulgaris Patients · recruiting
- NCT07530978 — ORAL HYGIENE, PERIODONTAL STATUS AND QUALITY OF LIFE · recruiting
- NCT06848790 — Interdental Hygiene Methods in Young Adults · NA · recruiting
Other Izmir Katip Celebi University trials
Trials by the same sponsor.
- NCT07460479 — Pilot Study of an Extended CBT Group Intervention for Intolerance of Uncertainty · NA · recruiting
- NCT07453277 — Blood-Based Molecular Clock Biomarkers Predict Acute Ischemic Stroke Onset: A Prospective Observational Study · active not recruiting
- NCT07341646 — Effect of Cuff Pressure Assessment Methods on Postoperative Complications in Breast Surgery · NA · not yet recruiting
- NCT07304661 — Comparison of PPV and LVOT VTI During Passive Leg Raising to Predict Fluid Responsiveness · not yet recruiting
- NCT07304648 — Role of End-Tidal CO2 During Passive Leg Raising to Predict Fluid Responsiveness in ICU · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04777487 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Izmir Katip Celebi University
- Last refreshed: 2 March 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04777487.
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