NCT04730882 (WBH001) is a clinical trial of Mixed Meal in Type 1 Diabetes, sponsored by University of Virginia.

Who is sponsoring NCT04730882?

NCT04730882 is sponsored by University of Virginia.

What drugs are being tested in NCT04730882?

Interventions in NCT04730882: Mixed Meal.

What condition does NCT04730882 study?

NCT04730882 studies Type 1 Diabetes, Hyperglycemia, Postprandial.

Is NCT04730882 still recruiting?

NCT04730882 is currently completed. Last updated 30 March 2025.

Last reviewed 2025-03-30 · How we verify

NCT04730882: WBH001

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Postprandial Hyperglycemia on Vasculature in Type 1 Diabetes and Healthy Adults

Completed Last updated 30 March 2025

What this trial tests

trial testing Mixed Meal in Type 1 Diabetes in 36 participants. Completed in 18 October 2024.

Timeline

6 April 2021

Primary endpoint
18 October 2024

18 October 2024

Quick facts

Lead sponsor	University of Virginia
Status	Completed
Study type	OBSERVATIONAL
Enrollment	36
Start date	6 April 2021
Primary completion	18 October 2024
Estimated completion	18 October 2024
Sites	1 location across United States

Drugs / interventions tested

Mixed Meal

Conditions studied

Type 1 Diabetes — all drugs for Type 1 Diabetes →
Hyperglycemia, Postprandial — all drugs for Hyperglycemia, Postprandial →

Sponsor

University of Virginia

Who can join

Adults 18 to 35, any sex, with Type 1 Diabetes or Hyperglycemia, Postprandial. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To the investigator's knowledge, there are no data available in the current literature regarding the acute effects of postprandial hyperglycemia and insulin timing on myocardial perfusion in people with type 1 diabetes (T1D). Observational studies using CEU in type 2 diabetes demonstrate that postprandial hyperglycemia determines myocardial perfusion defects. The investigator hypothesizes that the combination of postprandial hyperglycemia and insulin increases pulse wave velocity (i.e., aortic stiffness) and myocardial vasoconstriction, thereby reducing myocardial perfusion in T1D when compared to healthy controls. Furthermore, the investigator hypothesizes in T1D that dosing insulin before meal intake will ameliorate these cardiovascular defects.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Type 1 Diabetes

Currently open trials in the same condition.

NCT07061574 — A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New On · Phase 1, PHASE2 · recruiting
NCT07360080 — Long-Term Outcomes of Teplizumab in Routine Clinical Care · recruiting
NCT07457580 — Real-World Study of Patients With Type 1 Diabetes Treated With Teplizumab as Part of Managed Access Programs (MAPs) · recruiting
NCT07212179 — Safety and Feasibility of a Self-Learning Bolus Calculator With Simplified Meal Announcement in Adolescents With Type 1 · NA · recruiting
NCT07287943 — To Study the Efficacy and Safety of Medtronic 780G Insulin Pump in People With Gastroparesis and Type 1 Diabetes. · NA · recruiting

Other University of Virginia trials

Trials by the same sponsor.

NCT05880355 — Multimodality Cardiovascular Imaging for the Translation of Therapies for Vascular Activation After MI · EARLY_PHASE1 · not yet recruiting
NCT07405645 — Stereotactic MRI-guided Focused Ultrasound Mesencephalotomy · NA · recruiting
NCT07146685 — Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study · Phase 4 · not yet recruiting
NCT07298941 — Resilience Enhancement Following Sleep Treatment · Phase 2 · recruiting
NCT07036315 — Meaning in Music-Based Pain Modulation · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04730882 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Virginia
Last refreshed: 30 March 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04730882.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing