NCT04722276: PEEP

Fraction of Oxygen on Induction of Anesthesia in Infants

Completed NA Last updated 7 November 2023

What this trial tests

NA trial testing positive end expiratory pressure in Apnea in 84 participants. Completed in 1 July 2023.

Timeline

1 February 2021

Primary endpoint
1 July 2023

1 July 2023

Quick facts

Lead sponsor	Seoul National University Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	84
Start date	1 February 2021
Primary completion	1 July 2023
Estimated completion	1 July 2023
Sites	1 location across South Korea

Drugs / interventions tested

• positive end expiratory pressure
• fraction of inspired oxygen 80%

Conditions studied

• Apnea — all drugs for Apnea →

Sponsor

Seoul National University Hospital

Who can join

Adults 1 Month to 12 Months, any sex, with Apnea. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Invesetigators evaluated the effect of positive end-expiratory pressure during anaesthesia induction on nonhypoxic apnoea time in infants. Invesetigators assigned infants to a 7 cmH2O positive end expiratory pressure (PEEP) with fraction of inspired oxygen 80% or 0 cmH2O PEEP with fraction of oxygen 80% group. Anaesthesia was induced with 0.02 mg kg atropine, 5 mg kg thiopental sodium and 3 to 5% sevoflurane, and neuromuscular blockade with 0.6 mg kg rocuronium. Thereafter, 80% oxygen was provided via face mask with volume-controlled ventilation of 6 ml kg tidal volume, and either 7 cmH2O or no positive end-expiratory pressure. After 3 min of ventilation, the infants' trachea was intubated but disconnected from the breathing circuit, and ventilation resumed when pulse oximetry reached 95%.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.