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NCT04190953
Upper Airway's Pressure Drop Analyses After Mandibular Advancement and Maxillary Expansion
NA trial testing Twin block then Hyrax in Apnea in 90 participants. Currently enrolling.
1 March 2027
Quick facts
| Lead sponsor | University of Alberta |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | other |
| Enrollment | 90 |
| Start date | 18 February 2020 |
| Primary completion | 1 March 2027 |
| Estimated completion | 1 March 2027 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Twin block then Hyrax
- Hyrax then Twin block
Conditions studied
- Apnea — all drugs for Apnea →
- Airway Obstruction, Nasal — all drugs for Airway Obstruction, Nasal →
- Mandible Small — all drugs for Mandible Small →
- Maxillary Hypoplasia — all drugs for Maxillary Hypoplasia →
Sponsor
University of Alberta
Who can join
Adults 8 to 14, any sex, with Apnea or Airway Obstruction, Nasal. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Breathing is a crucial function for everyone. Breathing impairment in children could lead to behavioral and cognitive problems at least. But what if orthodontic treatment could help those patients to breathe better, with less effort? This research proposal aims to find out if the increase in the upper airway volume seen in some research results can be related to a decrease in respiratory effort and an improvement in the breathing capacity of those patients. In other words, if a tube shape is changed or if a tube is enlarged, would the airflow passing inside the tube change in velocity? Or would there be more air? Therefore, investigating the pressure/airflow, volume/lumen relation and its possible changes after mandibular repositioning and maxillary expansion in children will lead to a better understanding of how orthodontics could potentially affect the upper airway. Previous studies have reported a link between mandibular advancement appliances and maxillary appliances to an increase in the upper airway volume. However, more studies are needed to evaluate the relationship between the changes in the upper airway volume and actual airflow and respiratory capability. The airway volume measurement is important to, preliminary, state if there is an increase in the upper airway after orthodontic treatment. However a change in shape, even with the same volume, can affect the pressure and airflow. In this sense, the pressure drop analysis will allow an answer to those questions
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
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Related trials
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Currently open trials in the same condition.
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Other University of Alberta trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04190953 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Alberta
- Last refreshed: 18 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04190953.
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