NCT04950894 (OSPREY) is a NA clinical trial of Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea, sponsored by LivaNova.

Who is sponsoring NCT04950894?

NCT04950894 is sponsored by LivaNova.

What drugs are being tested in NCT04950894?

Interventions in NCT04950894: Hypoglossal Nerve Stimulation.

What condition does NCT04950894 study?

NCT04950894 studies Obstructive Sleep Apnea, OSA, Apnea, Apnea, Obstructive, Apnea, Obstructive Sleep, Apnea+Hypopnea, Hypopnea, Sleep.

Is NCT04950894 still recruiting?

NCT04950894 is currently active, enrolled. Last updated 1 May 2025.

Last reviewed 2025-05-01 · How we verify

NCT04950894: OSPREY

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Treating Obstructive Sleep Apnea Using Targeted Hypoglossal Neurostimulation

Active, enrolled NA Last updated 1 May 2025

What this trial tests

NA trial testing Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea in 150 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

27 July 2021

Primary endpoint
30 October 2024

30 October 2025

Quick facts

Lead sponsor	LivaNova
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	150
Start date	27 July 2021
Primary completion	30 October 2024
Estimated completion	30 October 2025
Sites	20 locations across United States

Drugs / interventions tested

Hypoglossal Nerve Stimulation

Conditions studied

Obstructive Sleep Apnea — all drugs for Obstructive Sleep Apnea →
OSA — all drugs for OSA →
Apnea — all drugs for Apnea →
Apnea, Obstructive — all drugs for Apnea, Obstructive →

Sponsor

LivaNova — full company profile →

Who can join

22 and older, any sex, with Obstructive Sleep Apnea or OSA. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Multi-center, open-label, prospective, randomized clinical trial of the aura6000(R) System for the reduction of apnea and hypopneas in adult patients with moderate to severe obstructive sleep apnea who have failed or are unwilling to use positive airway pressure treatment.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Reimagining obstructive sleep apnoea: a new era for sleep medicine.
Kundel V, Cohen O, Shah N. · · 2023 · cited 5× · PMID 37914468 · DOI 10.1016/s2213-2600(23)00372-7
Design and rationale for the treating Obstructive Sleep Apnea using Targeted Hypoglossal Nerve Stimulation (OSPREY) trial.
Jacobowitz O, Schwartz AR, Lovett EG, Ranuzzi G, et al · · 2022 · cited 5× · PMID 35613672 · DOI 10.1016/j.cct.2022.106804
Proximal Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea in the OSPREY Study : A Randomized Controlled Trial.
Malhotra A, Schwartz AR, Lovett E, Juran N, et al · · 2026 · PMID 42008810 · DOI 10.7326/annals-25-04414

Verify or expand the search:

Other trials of Hypoglossal Nerve Stimulation

Trials testing the same drug.

NCT04322097 — Mechanisms of Upper Airway Obstruction · NA · completed

Other recruiting trials for Obstructive Sleep Apnea

Currently open trials in the same condition.

NCT07195253 — Oro-myofunctional Characteristics and Obstructive Sleep Apnea in Infants With Down Syndrome · recruiting
NCT07273019 — Tongue Muscular Assessment in Children With Sleep Disordered Breathing · NA · recruiting
NCT07447011 — Glaucoma Respsosne to Lifestyle Corrections in Sleep Apnea · NA · recruiting
NCT07397780 — RPMO2 Oximeter Accuracy During Sleep 1 Trial · active not recruiting
NCT06698809 — Obstructive Sleep Apnea Therapeutic Intervention for REsiDual Sleepiness · NA · recruiting

Other LivaNova trials

Trials by the same sponsor.

NCT05975931 — IMPACT of AspireSR® for VNS Therapy on Healthcare Resource Utilisation and Clinical Outcomes. · terminated
NCT04779814 — Non-interventional Study Describing Healthcare Resource Utilisation and Clinical Outcomes Associated With VNS Therapy in · terminated
NCT04753385 — The RECOVER sUb-study, Which Leverages quaNtitative and Credible Research tOols From Verily, Will providE Assessment mea · terminated
NCT04282681 — XLTCS - Accelerometer Data Collection in an Epilepsy Monitoring Unit (EMU) · withdrawn
NCT03887715 — A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Thera · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04950894 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by LivaNova
Last refreshed: 1 May 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04950894.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing