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NCT04676958: TAKEOVER
viTAmin K2 and rEcOVery From ExeRcise
Completed
NA
Last updated 28 November 2023
What this trial tests
NA trial testing Vitamin K2 in Inflammation in 80 participants. Completed in 1 July 2023.
Timeline
1 April 2021
Primary endpoint
1 July 2023
1 July 2023
1 July 2023
Quick facts
| Lead sponsor | University of Glasgow |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 80 |
| Start date | 1 April 2021 |
| Primary completion | 1 July 2023 |
| Estimated completion | 1 July 2023 |
| Sites | 2 locations across United Kingdom |
Drugs / interventions tested
- Vitamin K2 — full drug profile →
- Micro-crystalline cellulose — full drug profile →
Conditions studied
- Inflammation — all drugs for Inflammation →
- Oxidative Stress — all drugs for Oxidative Stress →
- Vitamin K — all drugs for Vitamin K →
- Exercise — all drugs for Exercise →
Sponsor
University of Glasgow
Who can join
18 and older, any sex, with Inflammation or Oxidative Stress. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the current study, therefore, is to investigate the effects of vitamin K2 supplementation on the physiological responses to an acute bout of resistance exercise.
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities.
Jadhav N, Ajgaonkar S, Saha P, Gurav P, et al · · 2022 · cited 51× · PMID 35774605 · DOI 10.3389/fphar.2022.896920 -
Sarcopenia in chronic kidney disease: from bench to bedside.
Kim DW, Song SH. · · 2023 · cited 18× · PMID 37077132 · DOI 10.3904/kjim.2022.338 -
Protocol for a randomised controlled trial to investigate the effects of vitamin K2 on recovery from muscle-damaging resistance exercise in young and older adults-the TAKEOVER study.
Lithgow H, Johnston L, Ho FK, Celis-Morales C, et al · · 2022 · cited 5× · PMID 36539791 · DOI 10.1186/s13063-022-06937-y -
The Effects of Vitamin K2 on Recovery from Muscle-Damaging Resistance Exercise in Young and Older Adults: The TAKEOVER Randomized Controlled Trial.
Lithgow H, Johnston L, Ho F, Dunning E, et al · · 2026 · PMID 41843412 · DOI 10.1249/mss.0000000000003901 -
Protocol for a randomised controlled trial to investigate the effects of vitamin K2 on recovery from muscle damaging resistance exercise in young and older adults – The TAKEOVER study
Lithgow H, Johnston L, Ho FK, Celis-Morales C, et al · · 2022 · DOI 10.21203/rs.3.rs-1020009/v1
Verify or expand the search:
- PubMed search for NCT04676958
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
Data sources for this page
- Trial protocol + status: ClinicalTrials.gov NCT04676958 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Glasgow
- Last refreshed: 28 November 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04676958.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing