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NCT04662047: ONAIR
The Impact of Air Pollution on the Consumption of Antimicrobials in the General Population
trial in Community-acquired Pneumonia in 3,249,128 participants. Status unknown.
31 December 2023
Quick facts
| Lead sponsor | Hospital Universitari de Bellvitge |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 3,249,128 |
| Start date | 1 January 2021 |
| Primary completion | 31 December 2023 |
| Estimated completion | 31 December 2023 |
| Sites | 1 location across Spain |
Conditions studied
- Community-acquired Pneumonia — all drugs for Community-acquired Pneumonia →
- Air Pollution — all drugs for Air Pollution →
- Drug Resistance, Microbial — all drugs for Drug Resistance, Microbial →
Sponsor
Hospital Universitari de Bellvitge
Who can join
Eligibility, any sex, with Community-acquired Pneumonia or Air Pollution. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Objectives: To test the hypothesis that certain levels of air pollution may lead to increases in 1) antimicrobial consumption in the general population and 2) the presence of antibiotic resistance genes. Methods: The project will consist of two sub-studies: 1. A time series analysis of the association between daily antimicrobial consumption and air pollution in the 11 largest cities in Catalonia (2006-2022). Outcome variable: daily consumption of antimicrobials. Independent variables: air pollution and confounding variables. The analysis will use generalized additive models: through a random effects meta-analysis, the concentration-response estimates for each city will be added together to calculate the overall estimates. 2. Descriptive observational study of the relationship between the concentration of resistance genes and antimicrobial consumption in the Barcelona area (2021-2023). Outcome variable: concentration of antibiotic resistance genes. Independent variables: defined daily dose of antimicrobials per 1000 inhabitants-day. Descriptive analysis of the concentration and diversity of antibiotic resistance genes according to air quality monitoring station (urban vs. hospital environment), month, and correlation with antimicrobial consumption.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Short-Term Exposure to Ambient Air Pollution and Antimicrobial Use for Acute Respiratory Symptoms.
Abelenda-Alonso G, Satorra P, Marí-Dell'Olmo M, Tebé C, et al · · 2024 · cited 7× · PMID 39240563 · DOI 10.1001/jamanetworkopen.2024.32245
Verify or expand the search:
- PubMed search for NCT04662047
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04662047 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital Universitari de Bellvitge
- Last refreshed: 25 January 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04662047.
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