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NCT06653192
EUS-guided Choledochoduodenostomy vs ERCP as First Line in Malignant Distal Obstruction (CARPEDIEM Trial)
NA trial testing Endoscopic biliary drainage in Malignant Biliary Obstruction in 120 participants. Currently enrolling.
6 June 2027
Quick facts
| Lead sponsor | Hospital Universitari de Bellvitge |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 120 |
| Start date | 6 May 2025 |
| Primary completion | 6 June 2027 |
| Estimated completion | 6 May 2028 |
| Sites | 10 locations across Spain |
Drugs / interventions tested
- Endoscopic biliary drainage
- Self-expandable metallic stent (SEMS)
- Lumen-apposing metal stent (LAMS) and double-pigtail plastic stent (DPPS)
Conditions studied
- Malignant Biliary Obstruction — all drugs for Malignant Biliary Obstruction →
- Pancreatic Cancer — all drugs for Pancreatic Cancer →
- Biliary Tract Neoplasms — all drugs for Biliary Tract Neoplasms →
Sponsor
Hospital Universitari de Bellvitge
Who can join
18 and older, any sex, with Malignant Biliary Obstruction or Pancreatic Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this clinical trial is to evaluate the biliary drainage technical failure rate and/or the postprocedure acute pancreatitis rate between EUS-CDS vs ERCP procedures in patients with distal malignant biliary obstruction.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06653192
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Endoscopic biliary drainage
Trials testing the same drug.
- NCT06375954 — EUS-guided CDS vs ERCP as First Line in Malignant Distal Obstruction in Borderline Disease (CARPEDIEM-2 Trial) · NA · not yet recruiting
- NCT06375928 — EUS-guided Choledochoduodenostomy vs ERCP as First Line in Malignant Distal Obstruction in Resectable Disease (CARPEDIEM · NA · not yet recruiting
- NCT06671418 — Primary Percutaneous Stenting Above the Ampulla Versus Endoscopic Drainage for Unresectable Malignant Hilar Biliary Obst · Phase 3 · enrolling by invitation
Other recruiting trials for Malignant Biliary Obstruction
Currently open trials in the same condition.
- NCT05169398 — EUS-guided Hepatico-gastrostomy Using a Novel Lumen Apposing Metal Stent · NA · recruiting
Other Hospital Universitari de Bellvitge trials
Trials by the same sponsor.
- NCT07522931 — Morphometric Study of the Female Pelvic and Lower Abdominal Retroperitoneum in Cadavers · recruiting
- NCT07155590 — Subphenotype- and Complication-guided Adjunctive Fosfomycin Therapy for Staphylococcus Aureus Bacteraemia · active not recruiting
- NCT07178483 — Evaluation of Physical Capacity and Energy Requirements in Patients With Hypoxemic Acute Respiratory Failure · active not recruiting
- NCT06955221 — Effect of Alcohol Sclerotherapy on Pelvic Pain and Quality of Life in Women With Ovarian Endometriosis · NA · recruiting
- NCT06499064 — EOSS-ATTR Study (eHealth Based Operative Support System in ATTR-CM) · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06653192 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital Universitari de Bellvitge
- Last refreshed: 29 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06653192.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing