Last reviewed · How we verify
NCT04653064: WASABI
The Warmth, Anticipation, Sensation, Aversion, and Body-part Imaging Study
NA trial testing Placebo Cream in Pain in 150 participants. Currently enrolling.
26 February 2026
Quick facts
| Lead sponsor | Trustees of Dartmouth College |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 150 |
| Start date | 19 March 2021 |
| Primary completion | 26 February 2026 |
| Estimated completion | 26 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Placebo Cream
- Control Cream
Conditions studied
- Pain — all drugs for Pain →
Sponsor
Trustees of Dartmouth College
Who can join
18 and older, any sex, with Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This functional magnetic-resonance imaging study of the brain will feature a within-subject crossover design to investigate the effects of a placebo cream on painful thermal stimulation rendered upon eight body sites. The investigators aim to 1.) improve the understanding of how the brain represents thermal pain responses somatotopically (i.e., across different body-sites) 2.) to test these brain representations with and without the presence of a pain-targeted placebo intervention, and 3.) to examine how these brain representations change prior to vs. during the delivery of thermal pain. They predict that placebo cream will downregulate the intensity of aversive brain activity representations, and to a lesser degree, sensation and somatotopic representations, both prior to and during painful thermal stimulation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04653064
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Control Cream
Trials testing the same drug.
- NCT03781570 — Brain and Genetic Predictors of Individual Differences in Pain and Analgesia · completed
Other recruiting trials for Pain
Currently open trials in the same condition.
- NCT07533409 — Tactile and Pain Sensory Thresholds and Hand Grip Strength · recruiting
- NCT07294092 — Ketamine and Propofol NeuroImaging · EARLY_PHASE1 · recruiting
- NCT07290205 — Remimazolam NeuroImaging · EARLY_PHASE1 · recruiting
- NCT07487610 — Relationship Between Neuropathic Pain and Geriatric Assessment Parameters in Patients Aged 80 Years and Older · recruiting
- NCT07454993 — The Effect of Music During Colonoscopy · NA · recruiting
Other Trustees of Dartmouth College trials
Trials by the same sponsor.
- NCT04646460 — Context Interventions: Social Modeling and Initial Treatment Experience · NA · not yet recruiting
- NCT04669093 — Individual Differences in Placebo Analgesic Effects · NA · not yet recruiting
- NCT07528378 — Manipulating Social Percepts During fMRI · not yet recruiting
- NCT04650841 — The Role of the Opioid System in Placebo Effects on Pain and Social Rejection · EARLY_PHASE1 · not yet recruiting
- NCT07454733 — Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers? · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04653064 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Trustees of Dartmouth College
- Last refreshed: 14 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04653064.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing