Last reviewed · How we verify
NCT04646460
Context Interventions: Social Modeling and Initial Treatment Experience
NA trial testing Observed Success in Placebo Effect in 120 participants. Not yet recruiting.
1 December 2027
Quick facts
| Lead sponsor | Trustees of Dartmouth College |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | factorial |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 120 |
| Start date | 1 December 2026 |
| Primary completion | 1 December 2027 |
| Estimated completion | 1 December 2028 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Observed Success
- Observed Failure
- Experienced Success
- Experienced Failure
Conditions studied
- Placebo Effect — all drugs for Placebo Effect →
- Pain — all drugs for Pain →
Sponsor
Trustees of Dartmouth College
Who can join
Adults 18 to 55, any sex, with Placebo Effect or Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this experiment, the investigators study the brain pathways underlying several promising context interventions that enhance the strength of placebo effects. Specifically, the investigators examine the separate and joint effects of two of the most powerful context interventions: Social modeling-observing someone else being effectively treated-and prior treatment success or failure experiences. Participants will be randomized into 4 groups (Social modeling: observed success vs. observed failure and Conditioning: experienced success vs. experienced failure). The objectives are to investigate the placebo effect on pain relief and aversive image stimuli between and within-subjects. Each group will undergo a behavioral induction phase, fMRI placebo test phase, and an identical 3-month follow up fMRI placebo test phase. Follow-up assessment will provide some of the first evidence on predictors of the durability of placebo and context interventions.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04646460
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Placebo Effect
Currently open trials in the same condition.
- NCT06980090 — Neural Mechanisms of Interpersonal Expectations on Negative Affect · NA · recruiting
- NCT06423365 — A Tool to Help Patients With Muscle Symptoms After Taking a Statin Medication. · NA · active not recruiting
Other Trustees of Dartmouth College trials
Trials by the same sponsor.
- NCT04669093 — Individual Differences in Placebo Analgesic Effects · NA · not yet recruiting
- NCT04650841 — The Role of the Opioid System in Placebo Effects on Pain and Social Rejection · EARLY_PHASE1 · not yet recruiting
- NCT07528378 — Manipulating Social Percepts During fMRI · not yet recruiting
- NCT07454733 — Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers? · NA · not yet recruiting
- NCT07108101 — Interactions Between Placebo Effects and Mindful Awareness State · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04646460 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Trustees of Dartmouth College
- Last refreshed: 16 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04646460.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing