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NCT04604210
Symptom-specific TMS Targets for Depression and Anxiety
Phase 2 trial testing Transcranial magnetic stimulation in Depression in 40 participants. Completed in 28 December 2023.
28 December 2023
Quick facts
| Lead sponsor | Brigham and Women's Hospital |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 40 |
| Start date | 3 February 2021 |
| Primary completion | 28 December 2023 |
| Estimated completion | 28 December 2023 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Transcranial magnetic stimulation — full drug profile →
Conditions studied
- Depression — all drugs for Depression →
- Anxiety — all drugs for Anxiety →
- Major Depressive Disorder — all drugs for Major Depressive Disorder →
Sponsor
Brigham and Women's Hospital
Who can join
Adults 18 to 65, any sex, with Depression or Anxiety. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This pilot study aims to compare two different treatment targets for transcranial magnetic stimulation, an FDA-approved treatment for major depressive disorder (MDD), in terms of their relative efficacy for depression versus anxiety.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
A randomized trial comparing beam F3 and 5.5 cm targeting in rTMS treatment of depression demonstrates similar effectiveness.
Trapp NT, Pace BD, Neisewander B, Ten Eyck P, et al · · 2023 · cited 31× · PMID 37714408 · DOI 10.1016/j.brs.2023.09.006 -
Circuit-targeted modulation of anxiety symptoms in individuals with major depression: A randomized head-to-head TMS trial.
Taylor JJ, Li J, Lin C, Jones E, et al · · 2026 · PMID 41912790 · DOI 10.1038/s41380-026-03535-1
Verify or expand the search:
- PubMed search for NCT04604210
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04604210 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Brigham and Women's Hospital
- Last refreshed: 1 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04604210.
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