Last reviewed · How we verify
NCT04593498: ESA-AF
Excessive Supraventricular Activity and Atrial Fibrillation
trial testing Holter recording in Atrial Fibrillation in 250 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | Karolinska Institutet |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 250 |
| Start date | 1 November 2022 |
| Primary completion | 31 December 2026 |
| Estimated completion | 15 February 2028 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Holter recording
- Echocardiography (Echo)
- Blood sample — full drug profile →
- 24 hour ambulatory blood pressure monitoring And Arteriograph
Conditions studied
- Atrial Fibrillation — all drugs for Atrial Fibrillation →
- Atrial Flutter — all drugs for Atrial Flutter →
- Supraventricular Beat, Premature — all drugs for Supraventricular Beat, Premature →
- Premature Supraventricular Beats — all drugs for Premature Supraventricular Beats →
Sponsor
Karolinska Institutet
Who can join
Adults 70 to 89, any sex, with Atrial Fibrillation or Atrial Flutter. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the proposed study is to determine if individuals with excessive supraventricular ectopic activity (ESVEA) on Holter recording should be subjected to prolonged screening with Event loop recorder in order to detect previously undiagnosed Atrial fibrillation / flutter. Other biomarkers such as plasma biomarkers, high-end echocardiography and assessment of blood pressure and atrial stiffness will be studied and compared in ESVEA and control group as well as progression of atrial cardiomyopathy in ESVEA patients.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Atrial fibrillation: epidemiology, screening and digital health.
Linz D, Gawalko M, Betz K, Hendriks JM, et al · · 2024 · cited 230× · PMID 38362546 · DOI 10.1016/j.lanepe.2023.100786
Verify or expand the search:
- PubMed search for NCT04593498
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04593498 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Karolinska Institutet
- Last refreshed: 6 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04593498.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing