NCT07442032 (CaPS) is a clinical trial in Sepsis, sponsored by Karolinska Institutet.

Who is sponsoring NCT07442032?

NCT07442032 is sponsored by Karolinska Institutet.

What condition does NCT07442032 study?

NCT07442032 studies Sepsis, Septic Shock, Cardiovascular Dysfunction, Microcirculatory Dysfunction, Troponin Elevation, Peripheral Vascular Response.

Is NCT07442032 still recruiting?

NCT07442032 is currently not yet recruiting. Last updated 2 March 2026.

Last reviewed 2026-03-02 · How we verify

NCT07442032: CaPS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cardiovascular Phenotypes in Sepsis

Not yet recruiting Last updated 2 March 2026

What this trial tests

trial in Sepsis in 400 participants. Not yet recruiting.

Timeline

6 April 2026

Primary endpoint
1 May 2028

31 December 2029

Quick facts

Lead sponsor	Karolinska Institutet
Status	Not yet recruiting
Study type	OBSERVATIONAL
Enrollment	400
Start date	6 April 2026
Primary completion	1 May 2028
Estimated completion	31 December 2029

Conditions studied

Sepsis — all drugs for Sepsis →
Septic Shock — all drugs for Septic Shock →
Cardiovascular Dysfunction — all drugs for Cardiovascular Dysfunction →
Microcirculatory Dysfunction — all drugs for Microcirculatory Dysfunction →

Sponsor

Karolinska Institutet

Who can join

18 and older, any sex, with Sepsis or Septic Shock. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This prospective observational study will investigate cardiovascular phenotypes in adults with sepsis and hemodynamic instability. Approximately 400 patients requiring vasopressor support will be enrolled across multiple hospital sites. Within 72 hours of admission, participants will undergo peripheral vascular assessments, echocardiography, and blood sampling for cardiac, endothelial, and inflammatory biomarkers. Patients will be classified according to the presence or absence of peripheral vascular dysfunction and cardiac dysfunction. The primary aim is to examine the association between these cardiovascular phenotypes and one-year mortality. Secondary aims include evaluating biomarker profiles, characterizing myocardial injury, and assessing cardiac function at a 3-month follow-up. The study seeks to improve understanding of sepsis-related cardiovascular dysfunction and support development of more individualized management strategies.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

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Other Karolinska Institutet trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07442032 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Karolinska Institutet
Last refreshed: 2 March 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07442032.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing