NCT04588740 is a Phase 1 clinical trial of concentrated beet root juice in Healthy, sponsored by University of Virginia.

Who is sponsoring NCT04588740?

NCT04588740 is sponsored by University of Virginia.

What drugs are being tested in NCT04588740?

Interventions in NCT04588740: concentrated beet root juice, Placebo beet root juice.

Is NCT04588740 still recruiting?

NCT04588740 is currently completed. Last updated 8 May 2024.

Last reviewed 2024-05-08 · How we verify

NCT04588740

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Inorganic Nitrate: Sex Differences in Muscle Contractile Function and Efficiency

Completed Phase 1 Last updated 8 May 2024

What this trial tests

Phase 1 trial testing concentrated beet root juice in Healthy in 35 participants. Completed in 30 December 2023.

Timeline

20 January 2020

Primary endpoint
30 December 2023

30 December 2023

Quick facts

Lead sponsor	University of Virginia
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	other
Enrollment	35
Start date	20 January 2020
Primary completion	30 December 2023
Estimated completion	30 December 2023
Sites	1 location across United States

Drugs / interventions tested

concentrated beet root juice — full drug profile →
Placebo beet root juice — full drug profile →

Conditions studied

Healthy — all drugs for Healthy →

Sponsor

University of Virginia

Who can join

Adults 18 to 34, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Dietary inorganic nitrate, in the form of beet root juice, is a nutritional intervention, considered to be an exercise enhancer due to its capacity to increase Nitric Oxide (NO) bioavailability. Increasing NO bioavailability has been associated with improved mitochondrial respiration, muscle tissue perfusion and contractile function which may lead to improved exercise capacity. However, the majority of the literature is on male subjects. This limits the applicability of this supplement in females. Therefore, our project aims to determine sex-differences and the specific sex-response across the menstrual cycle of dietary nitrate supplementation on exercise efficiency, strength and fatigue resistance.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

The effects of inorganic nitrate supplementation on exercise economy and endurance capacity across the menstrual cycle.
Hogwood AC, Ortiz de Zevallos J, Kruse K, De Guzman J, et al · · 2023 · cited 9× · PMID 37732374 · DOI 10.1152/japplphysiol.00221.2023
The influence of sex on the effects of inorganic nitrate supplementation on muscular power and endurance.
Ortiz de Zevallos J, Hogwood AC, Kruse K, De Guzman J, et al · · 2024 · cited 3× · PMID 39417813 · DOI 10.1152/japplphysiol.00321.2024

Verify or expand the search:

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Other University of Virginia trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04588740 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Virginia
Last refreshed: 8 May 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04588740.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing