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NCT04442659: PHPLAVO
Prehospital Prediction of Large Anterior Vessel Occlusion
trial testing pre hospital triage tool in Stroke, Acute in 2,000 participants. Completed in 1 January 2020.
1 October 2019
Quick facts
| Lead sponsor | Leiden University Medical Center |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 2,000 |
| Start date | 1 July 2018 |
| Primary completion | 1 October 2019 |
| Estimated completion | 1 January 2020 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- pre hospital triage tool
Conditions studied
- Stroke, Acute — all drugs for Stroke, Acute →
Sponsor
Leiden University Medical Center
Who can join
18 and older, any sex, with Stroke, Acute. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
For the clinical benefit of intravenous thrombolysis "IVT" or intra-arterial thrombectomy "IAT" time is the most crucial factor. Reducing the time between stroke onset en treatment is therefore a major goal. Since IAT is only suitable for stroke due to large anterior vessel occlusion "LAVO" which is only performed in specialized comprehensive stroke centers "CSC", triage of LAVO-patients in the prehospital phase (i.e. in the ambulance) in order to directly allocate them to such a specialized CSC will save vital time (time=brain!). Several LAVO-prediction scales for clinical triage have been developed but most were tested in- hospital by experienced neurologists. Consequently, there is a great need for validation of these scales in the prehospital setting by Emergency Medical Services "EMS" personnel. Objective: to recalibrate, validate performance and assess feasibility of several existing LAVO-prediction scales in the prehospital phase (i.e. assessment by EMS personnel). Study design: multiregional, multicenter observational cohort study to investigate performance and feasibility of LAVO-prediction scales a. Study population: all patients potentially eligible for IVTIAT according to the protocol used by EMS personnel except for when younger than 18 years.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Prehospital Triage of Intracranial Hemorrhage and Anterior Large-Vessel Occlusion Ischemic Stroke: Value of the Rapid Arterial Occlusion Evaluation.
Dekker L, Geraedts VJ, Hubert J, Duijndam D, et al · · 2023 · PMID 41585051 · DOI 10.1161/svin.123.000947
Verify or expand the search:
- PubMed search for NCT04442659
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Stroke, Acute
Currently open trials in the same condition.
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- NCT06123650 — Post Stroke Dysphagia: Effect of Adding rTMS to Conventional Therapy on the Prevalence of Pneumonia. · NA · recruiting
Other Leiden University Medical Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04442659 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Leiden University Medical Center
- Last refreshed: 22 June 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04442659.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing