NCT04392622 is a Phase 1 clinical trial of D-Limonene Gelcaps in Xerostomia, sponsored by Stanford University.

Who is sponsoring NCT04392622?

NCT04392622 is sponsored by Stanford University.

What drugs are being tested in NCT04392622?

Interventions in NCT04392622: D-Limonene Gelcaps, Intensity modulated radiotherapy (IMRT), Cisplatin, Xerostomia questionnaire.

What condition does NCT04392622 study?

NCT04392622 studies Xerostomia.

Is NCT04392622 still recruiting?

NCT04392622 is currently recruiting now. Last updated 20 July 2025.

Last reviewed 2025-07-20 · How we verify

NCT04392622

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

d-Limonene +Radiation +PlatinumBasedChemo for Xerostomia Prevention in LocallyAdvanced HNSCC

Recruiting now Phase 1 Last updated 20 July 2025

What this trial tests

Phase 1 trial testing D-Limonene Gelcaps in Xerostomia in 40 participants. Currently enrolling.

Timeline

15 February 2021

Primary endpoint
15 August 2027

15 May 2028

Quick facts

Lead sponsor	Stanford University
Phase	Phase 1
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	non randomized
Design	sequential
Masking	none
Primary purpose	supportive care
Enrollment	40
Start date	15 February 2021
Primary completion	15 August 2027
Estimated completion	15 May 2028
Sites	1 location across United States

Drugs / interventions tested

D-Limonene Gelcaps — full drug profile →
Intensity modulated radiotherapy (IMRT)
Cisplatin (cisplatin) — full drug profile →
Xerostomia questionnaire

Conditions studied

Xerostomia — all drugs for Xerostomia →

Sponsor

Stanford University

Who can join

18 and older, any sex, with Xerostomia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study explores the safety of d-limonene, a commercially-available dietary supplement (food) as a potential therapeutic for the severe dry mouth (xerostomia) experienced by patients with head and neck cancer as a side effect of their anti-cancer treatment.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Dietary fat and lipid metabolism in the tumor microenvironment.
Goswami S, Zhang Q, Celik CE, Reich EM, et al · · 2023 · cited 21× · PMID 37722512 · DOI 10.1016/j.bbcan.2023.188984
Salivary toxicity from PSMA-targeted radiopharmaceuticals: What we have learned and where we are going.
Muniz M, Loprinzi CL, Orme JJ, Koch RM, et al · · 2024 · cited 17× · PMID 38703593 · DOI 10.1016/j.ctrv.2024.102748
Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype.
Viswanathan V, Cao H, Saiki J, Jiang D, et al · · 2022 · cited 6× · PMID 35707206 · DOI 10.1093/pnasnexus/pgac056
A Computational Text Mining-Guided Meta-Analysis Approach to Identify Potential Xerostomia Drug Targets.
Beckman MF, Brennan EJ, Igba CK, Brennan MT, et al · · 2022 · cited 4× · PMID 35268532 · DOI 10.3390/jcm11051442

Verify or expand the search:

Other trials of D-Limonene Gelcaps

Trials testing the same drug.

NCT06647095 — New Non-invasive Biomarkers of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) · completed

Other recruiting trials for Xerostomia

Currently open trials in the same condition.

NCT07394842 — Longitudinal Oral Health Changes After Head and Neck Radiotherapy · active not recruiting
NCT06465628 — Acupressure on Xerostomia in Head and Neck Cancer Patients · NA · recruiting
NCT06365047 — Dry Mouth Toothpaste Study - Comparing Two Toothpastes With Arginine · Phase 3 · active not recruiting
NCT06194123 — Effect of Whitening Agent With Emulsion Gel in Saliva and Halitosis · NA · active not recruiting
NCT06287294 — An Investigation Into Taste Problems Associated With Xerostomia in Patients With Advanced Cancer · recruiting

Other Stanford University trials

Trials by the same sponsor.

NCT05945147 — Ketamine and Midazolam Infusions for CRPS: Feasibility Study · Phase 2 · withdrawn
NCT04225949 — Patients Understanding of PROM Graphs · NA · withdrawn
NCT06273098 — School-Based Bladder Health Intervention · NA · withdrawn
NCT04652635 — Management of Nailbed Injuries · NA · withdrawn
NCT05443503 — Stanford Spine Keeper - Managing Your Low Back Pain · NA · suspended

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04392622 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Stanford University
Last refreshed: 20 July 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04392622.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing