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NCT04370119: SeCo
Screening for COVID-19 and Monitoring of Serological Responses to SARS-CoV-2 in Healthcare Workers
trial testing Nasal swab in SARS-CoV-2 in 1,092 participants. Completed in 27 April 2025.
23 April 2021
Quick facts
| Lead sponsor | University Medicine Greifswald |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 1,092 |
| Start date | 27 April 2020 |
| Primary completion | 23 April 2021 |
| Estimated completion | 27 April 2025 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Nasal swab — full drug profile →
- Serum testing
Conditions studied
- SARS-CoV-2 — all drugs for SARS-CoV-2 →
Sponsor
University Medicine Greifswald
Who can join
18 and older, any sex, with SARS-CoV-2. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The main objectives of this study are 1) to establish the prevalence of SARS-CoV-2 in asymptomatic healthcare workers (HCWs) in an early phase of community spread as well as 2) to monitor the future spread of the disease by assessing serological responses to SARS-CoV-2 in symptomatic and asymptomatic HCWs over time and 3) to improve the assessment of the immune response and its protective effect as well as the assessment of infectivity of affected HCWs and 4) to evaluate the value and significance of antibody formation and serological antibody tests and 5) to be able to evaluate possible future preventive and / or therapeutic approaches against SARS-CoV-2, e.g. to assess vaccination effects
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
A flow cytometric assay to detect platelet-activating antibodies in VITT after ChAdOx1 nCov-19 vaccination.
Handtke S, Wolff M, Zaninetti C, Wesche J, et al · · 2021 · cited 54× · PMID 33945605 · DOI 10.1182/blood.2021012064 -
The role of routine SARS-CoV-2 screening of healthcare-workers in acute care hospitals in 2020: a systematic review and meta-analysis.
Jabs JM, Schwabe A, Wollkopf AD, Gebel B, et al · · 2022 · cited 14× · PMID 35780088 · DOI 10.1186/s12879-022-07554-5 -
Platelet-activating histone/antihistone IgG complexes in anti-PF4-negative thrombosis and thrombocytopenia syndrome.
Esefeld M, Handtke S, Kaiser R, Nicolai L, et al · · 2025 · cited 5× · PMID 40179418 · DOI 10.1182/bloodadvances.2024015076
Verify or expand the search:
- PubMed search for NCT04370119
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University Medicine Greifswald trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04370119 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Medicine Greifswald
- Last refreshed: 20 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04370119.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing